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Potential Aggregation-Prone Regions in Complementarity-Determining Regions of Antibodies and Their Contribution Towards Antigen Recognition: A Computational Analysis

PURPOSE: To analyze contribution of short aggregation-prone regions (APRs), which may self-associate via cross-β motif and were earlier identified in therapeutic mAbs, towards antigen recognition via structural analyses of antibody-antigen complexes. METHODS: A dataset of 29 publically available hig...

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Detalles Bibliográficos
Autores principales:	Wang, Xiaoling, Singh, Satish K., Kumar, Sandeep
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2010
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088613/ https://www.ncbi.nlm.nih.gov/pubmed/20422267 http://dx.doi.org/10.1007/s11095-010-0143-5

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