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Synthesis and biological activity of water-soluble polymer complexes of arbidol

We have synthesized water-soluble complexes between the antiviral drug arbidol and polymer compounds with molecular masses of 19–31 kDa representing copolymers of acrylamide (AA) and 2-acrylamido-2-methylpropanesulfonic acid (AAMPS). The complexes are less toxic than arbidol and retain the high leve...

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Autores principales: Eropkin, M. Yu., Solovskii, M. V., Smirnova, M. Yu., Bryazzhikova, T. S., Gudkova, T. M., Konovalova, N. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088646/
https://www.ncbi.nlm.nih.gov/pubmed/32214534
http://dx.doi.org/10.1007/s11094-010-0351-7
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author Eropkin, M. Yu.
Solovskii, M. V.
Smirnova, M. Yu.
Bryazzhikova, T. S.
Gudkova, T. M.
Konovalova, N. I.
author_facet Eropkin, M. Yu.
Solovskii, M. V.
Smirnova, M. Yu.
Bryazzhikova, T. S.
Gudkova, T. M.
Konovalova, N. I.
author_sort Eropkin, M. Yu.
collection PubMed
description We have synthesized water-soluble complexes between the antiviral drug arbidol and polymer compounds with molecular masses of 19–31 kDa representing copolymers of acrylamide (AA) and 2-acrylamido-2-methylpropanesulfonic acid (AAMPS). The complexes are less toxic than arbidol and retain the high level of antiviral activity of this drug. The content of arbidol in the obtained complexes is within 26.4–32.1 mass%. The antiviral activity of the synthesized polymeric complexes against all studied viruses, including human epidemic influenza virus A (H3N2), bird highly pathogenic influenza virus A (H5N1), herpes type 1 virus (HSV-1), and adenovirus type III (AV-III) is comparable to the antiviral effect of nonmodified arbidol. The in vitro toxicity of the obtained complexes is about one order of magnitude lower than that of nonmodified arbidol; the pharmacological index, four times that of the initial low-molecular-weight drug. The synthesized water-soluble polymer complexes of arbidol can be useful in pharmacology since they can serve as the basis for new effective and safe parent antiviral substances and related formulations.
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spelling pubmed-70886462020-03-23 Synthesis and biological activity of water-soluble polymer complexes of arbidol Eropkin, M. Yu. Solovskii, M. V. Smirnova, M. Yu. Bryazzhikova, T. S. Gudkova, T. M. Konovalova, N. I. Pharm Chem J Article We have synthesized water-soluble complexes between the antiviral drug arbidol and polymer compounds with molecular masses of 19–31 kDa representing copolymers of acrylamide (AA) and 2-acrylamido-2-methylpropanesulfonic acid (AAMPS). The complexes are less toxic than arbidol and retain the high level of antiviral activity of this drug. The content of arbidol in the obtained complexes is within 26.4–32.1 mass%. The antiviral activity of the synthesized polymeric complexes against all studied viruses, including human epidemic influenza virus A (H3N2), bird highly pathogenic influenza virus A (H5N1), herpes type 1 virus (HSV-1), and adenovirus type III (AV-III) is comparable to the antiviral effect of nonmodified arbidol. The in vitro toxicity of the obtained complexes is about one order of magnitude lower than that of nonmodified arbidol; the pharmacological index, four times that of the initial low-molecular-weight drug. The synthesized water-soluble polymer complexes of arbidol can be useful in pharmacology since they can serve as the basis for new effective and safe parent antiviral substances and related formulations. Springer US 2010-02-04 2009 /pmc/articles/PMC7088646/ /pubmed/32214534 http://dx.doi.org/10.1007/s11094-010-0351-7 Text en © Springer Science+Business Media, Inc. 2009 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Eropkin, M. Yu.
Solovskii, M. V.
Smirnova, M. Yu.
Bryazzhikova, T. S.
Gudkova, T. M.
Konovalova, N. I.
Synthesis and biological activity of water-soluble polymer complexes of arbidol
title Synthesis and biological activity of water-soluble polymer complexes of arbidol
title_full Synthesis and biological activity of water-soluble polymer complexes of arbidol
title_fullStr Synthesis and biological activity of water-soluble polymer complexes of arbidol
title_full_unstemmed Synthesis and biological activity of water-soluble polymer complexes of arbidol
title_short Synthesis and biological activity of water-soluble polymer complexes of arbidol
title_sort synthesis and biological activity of water-soluble polymer complexes of arbidol
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088646/
https://www.ncbi.nlm.nih.gov/pubmed/32214534
http://dx.doi.org/10.1007/s11094-010-0351-7
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