Activities of proteasome and m-calpain are essential for Chikungunya virus replication

Replication of many viruses is dependent on the ubiquitin proteasome system. The present study demonstrates that Chikungunya virus replication increases proteasome activity and induces unfolded protein response (UPR) in cultured cells. Further, it was seen that the virus replication was dependent on...

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Detalles Bibliográficos
Autores principales: Karpe, Yogesh A., Pingale, Kunal D., Kanade, Gayatri D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088676/
https://www.ncbi.nlm.nih.gov/pubmed/27206501
http://dx.doi.org/10.1007/s11262-016-1355-5
Descripción
Sumario:Replication of many viruses is dependent on the ubiquitin proteasome system. The present study demonstrates that Chikungunya virus replication increases proteasome activity and induces unfolded protein response (UPR) in cultured cells. Further, it was seen that the virus replication was dependent on the activities of proteasomes and m-calpain. Proteasome inhibition induced accumulation of polyubiquitinated proteins and earlier visualization of UPR.

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