Activities of proteasome and m-calpain are essential for Chikungunya virus replication

Replication of many viruses is dependent on the ubiquitin proteasome system. The present study demonstrates that Chikungunya virus replication increases proteasome activity and induces unfolded protein response (UPR) in cultured cells. Further, it was seen that the virus replication was dependent on...

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Detalles Bibliográficos
Autores principales: Karpe, Yogesh A., Pingale, Kunal D., Kanade, Gayatri D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088676/
https://www.ncbi.nlm.nih.gov/pubmed/27206501
http://dx.doi.org/10.1007/s11262-016-1355-5
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author Karpe, Yogesh A.
Pingale, Kunal D.
Kanade, Gayatri D.
author_facet Karpe, Yogesh A.
Pingale, Kunal D.
Kanade, Gayatri D.
author_sort Karpe, Yogesh A.
collection PubMed
description Replication of many viruses is dependent on the ubiquitin proteasome system. The present study demonstrates that Chikungunya virus replication increases proteasome activity and induces unfolded protein response (UPR) in cultured cells. Further, it was seen that the virus replication was dependent on the activities of proteasomes and m-calpain. Proteasome inhibition induced accumulation of polyubiquitinated proteins and earlier visualization of UPR.
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spelling pubmed-70886762020-03-23 Activities of proteasome and m-calpain are essential for Chikungunya virus replication Karpe, Yogesh A. Pingale, Kunal D. Kanade, Gayatri D. Virus Genes Article Replication of many viruses is dependent on the ubiquitin proteasome system. The present study demonstrates that Chikungunya virus replication increases proteasome activity and induces unfolded protein response (UPR) in cultured cells. Further, it was seen that the virus replication was dependent on the activities of proteasomes and m-calpain. Proteasome inhibition induced accumulation of polyubiquitinated proteins and earlier visualization of UPR. Springer US 2016-05-20 2016 /pmc/articles/PMC7088676/ /pubmed/27206501 http://dx.doi.org/10.1007/s11262-016-1355-5 Text en © Springer Science+Business Media New York 2016 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Karpe, Yogesh A.
Pingale, Kunal D.
Kanade, Gayatri D.
Activities of proteasome and m-calpain are essential for Chikungunya virus replication
title Activities of proteasome and m-calpain are essential for Chikungunya virus replication
title_full Activities of proteasome and m-calpain are essential for Chikungunya virus replication
title_fullStr Activities of proteasome and m-calpain are essential for Chikungunya virus replication
title_full_unstemmed Activities of proteasome and m-calpain are essential for Chikungunya virus replication
title_short Activities of proteasome and m-calpain are essential for Chikungunya virus replication
title_sort activities of proteasome and m-calpain are essential for chikungunya virus replication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088676/
https://www.ncbi.nlm.nih.gov/pubmed/27206501
http://dx.doi.org/10.1007/s11262-016-1355-5
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