Delivery Systems and Local Administration Routes for Therapeutic siRNA

With the increasing number of studies proposing new and optimal delivery strategies for the efficacious silencing of gene-related diseases by the local administration of siRNAs, the present review aims to provide a broad overview of the most important and latest developments of non-viral siRNA deliv...

Descripción completa

Detalles Bibliográficos
Autores principales: Vicentini, Fabiana Testa Moura de Carvalho, Borgheti-Cardoso, Lívia Neves, Depieri, Lívia Vieira, de Macedo Mano, Danielle, Abelha, Thais Fedatto, Petrilli, Raquel, Bentley, Maria Vitória Lopes Badra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Expert Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088712/
https://www.ncbi.nlm.nih.gov/pubmed/23344907
http://dx.doi.org/10.1007/s11095-013-0971-1
Descripción
Sumario:With the increasing number of studies proposing new and optimal delivery strategies for the efficacious silencing of gene-related diseases by the local administration of siRNAs, the present review aims to provide a broad overview of the most important and latest developments of non-viral siRNA delivery systems for local administration. Moreover, the main disease targets for the local delivery of siRNA to specific tissues or organs, including the skin, the lung, the eye, the nervous system, the digestive system and the vagina, were explored.

Ejemplares similares