Delivery Systems and Local Administration Routes for Therapeutic siRNA

With the increasing number of studies proposing new and optimal delivery strategies for the efficacious silencing of gene-related diseases by the local administration of siRNAs, the present review aims to provide a broad overview of the most important and latest developments of non-viral siRNA deliv...

Descripción completa

Detalles Bibliográficos
Autores principales: Vicentini, Fabiana Testa Moura de Carvalho, Borgheti-Cardoso, Lívia Neves, Depieri, Lívia Vieira, de Macedo Mano, Danielle, Abelha, Thais Fedatto, Petrilli, Raquel, Bentley, Maria Vitória Lopes Badra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Expert Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088712/
https://www.ncbi.nlm.nih.gov/pubmed/23344907
http://dx.doi.org/10.1007/s11095-013-0971-1
_version_ 1783509595798372352
author Vicentini, Fabiana Testa Moura de Carvalho
Borgheti-Cardoso, Lívia Neves
Depieri, Lívia Vieira
de Macedo Mano, Danielle
Abelha, Thais Fedatto
Petrilli, Raquel
Bentley, Maria Vitória Lopes Badra
author_facet Vicentini, Fabiana Testa Moura de Carvalho
Borgheti-Cardoso, Lívia Neves
Depieri, Lívia Vieira
de Macedo Mano, Danielle
Abelha, Thais Fedatto
Petrilli, Raquel
Bentley, Maria Vitória Lopes Badra
author_sort Vicentini, Fabiana Testa Moura de Carvalho
collection PubMed
description With the increasing number of studies proposing new and optimal delivery strategies for the efficacious silencing of gene-related diseases by the local administration of siRNAs, the present review aims to provide a broad overview of the most important and latest developments of non-viral siRNA delivery systems for local administration. Moreover, the main disease targets for the local delivery of siRNA to specific tissues or organs, including the skin, the lung, the eye, the nervous system, the digestive system and the vagina, were explored.
format Online
Article
Text
id pubmed-7088712
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-70887122020-03-23 Delivery Systems and Local Administration Routes for Therapeutic siRNA Vicentini, Fabiana Testa Moura de Carvalho Borgheti-Cardoso, Lívia Neves Depieri, Lívia Vieira de Macedo Mano, Danielle Abelha, Thais Fedatto Petrilli, Raquel Bentley, Maria Vitória Lopes Badra Pharm Res Expert Review With the increasing number of studies proposing new and optimal delivery strategies for the efficacious silencing of gene-related diseases by the local administration of siRNAs, the present review aims to provide a broad overview of the most important and latest developments of non-viral siRNA delivery systems for local administration. Moreover, the main disease targets for the local delivery of siRNA to specific tissues or organs, including the skin, the lung, the eye, the nervous system, the digestive system and the vagina, were explored. Springer US 2013-01-24 2013 /pmc/articles/PMC7088712/ /pubmed/23344907 http://dx.doi.org/10.1007/s11095-013-0971-1 Text en © Springer Science+Business Media New York 2013 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Expert Review
Vicentini, Fabiana Testa Moura de Carvalho
Borgheti-Cardoso, Lívia Neves
Depieri, Lívia Vieira
de Macedo Mano, Danielle
Abelha, Thais Fedatto
Petrilli, Raquel
Bentley, Maria Vitória Lopes Badra
Delivery Systems and Local Administration Routes for Therapeutic siRNA
title Delivery Systems and Local Administration Routes for Therapeutic siRNA
title_full Delivery Systems and Local Administration Routes for Therapeutic siRNA
title_fullStr Delivery Systems and Local Administration Routes for Therapeutic siRNA
title_full_unstemmed Delivery Systems and Local Administration Routes for Therapeutic siRNA
title_short Delivery Systems and Local Administration Routes for Therapeutic siRNA
title_sort delivery systems and local administration routes for therapeutic sirna
topic Expert Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088712/
https://www.ncbi.nlm.nih.gov/pubmed/23344907
http://dx.doi.org/10.1007/s11095-013-0971-1
work_keys_str_mv AT vicentinifabianatestamouradecarvalho deliverysystemsandlocaladministrationroutesfortherapeuticsirna
AT borgheticardosolivianeves deliverysystemsandlocaladministrationroutesfortherapeuticsirna
AT depieriliviavieira deliverysystemsandlocaladministrationroutesfortherapeuticsirna
AT demacedomanodanielle deliverysystemsandlocaladministrationroutesfortherapeuticsirna
AT abelhathaisfedatto deliverysystemsandlocaladministrationroutesfortherapeuticsirna
AT petrilliraquel deliverysystemsandlocaladministrationroutesfortherapeuticsirna
AT bentleymariavitorialopesbadra deliverysystemsandlocaladministrationroutesfortherapeuticsirna

Ejemplares similares