2,3,7,8-Tetrachlorodibenzo-p-dioxin influences bovine herpesvirus 1 replication through upregulation of SIRT3 and cytoskeletal reorganization

Infection of kidney cells (MDBK) with Bovine Herpesvirus 1 (BoHV-1) is affected by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which accelerates BoHV-1-induced apoptosis and increases virus replication. Herein, to elucidate the mechanism through TCDD modifies BoHV-1 infection, we analyzed the modula...

Descripción completa

Detalles Bibliográficos
Autores principales: Fiorito, Filomena, Iovane, Valentina, Marullo, Annarosaria, Costagliola, Anna, Granato, Giovanna Elvira, De Martino, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088714/
https://www.ncbi.nlm.nih.gov/pubmed/29081026
http://dx.doi.org/10.1007/s11259-017-9701-1
_version_ 1783509596270231552
author Fiorito, Filomena
Iovane, Valentina
Marullo, Annarosaria
Costagliola, Anna
Granato, Giovanna Elvira
De Martino, Luisa
author_facet Fiorito, Filomena
Iovane, Valentina
Marullo, Annarosaria
Costagliola, Anna
Granato, Giovanna Elvira
De Martino, Luisa
author_sort Fiorito, Filomena
collection PubMed
description Infection of kidney cells (MDBK) with Bovine Herpesvirus 1 (BoHV-1) is affected by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which accelerates BoHV-1-induced apoptosis and increases virus replication. Herein, to elucidate the mechanism through TCDD modifies BoHV-1 infection, we analyzed the modulation of a members of Sirtuin proteins family in MDBK cells. We found that mitochondrial SIRT3 was upregulated during infection. This change was accompanied by cytoskeletal rearrangements and cell extensions. All these trends were drastically modified by TCDD. We hypothesize that, taken together, these results might further clarify the processes responsible for the action of TCDD on the BoHV-1 replication, resulting in enhanced virus production.
format Online
Article
Text
id pubmed-7088714
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Springer Netherlands
record_format MEDLINE/PubMed
spelling pubmed-70887142020-03-23 2,3,7,8-Tetrachlorodibenzo-p-dioxin influences bovine herpesvirus 1 replication through upregulation of SIRT3 and cytoskeletal reorganization Fiorito, Filomena Iovane, Valentina Marullo, Annarosaria Costagliola, Anna Granato, Giovanna Elvira De Martino, Luisa Vet Res Commun Original Article Infection of kidney cells (MDBK) with Bovine Herpesvirus 1 (BoHV-1) is affected by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which accelerates BoHV-1-induced apoptosis and increases virus replication. Herein, to elucidate the mechanism through TCDD modifies BoHV-1 infection, we analyzed the modulation of a members of Sirtuin proteins family in MDBK cells. We found that mitochondrial SIRT3 was upregulated during infection. This change was accompanied by cytoskeletal rearrangements and cell extensions. All these trends were drastically modified by TCDD. We hypothesize that, taken together, these results might further clarify the processes responsible for the action of TCDD on the BoHV-1 replication, resulting in enhanced virus production. Springer Netherlands 2017-10-28 2017 /pmc/articles/PMC7088714/ /pubmed/29081026 http://dx.doi.org/10.1007/s11259-017-9701-1 Text en © Springer Science+Business Media B.V. 2017 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Fiorito, Filomena
Iovane, Valentina
Marullo, Annarosaria
Costagliola, Anna
Granato, Giovanna Elvira
De Martino, Luisa
2,3,7,8-Tetrachlorodibenzo-p-dioxin influences bovine herpesvirus 1 replication through upregulation of SIRT3 and cytoskeletal reorganization
title 2,3,7,8-Tetrachlorodibenzo-p-dioxin influences bovine herpesvirus 1 replication through upregulation of SIRT3 and cytoskeletal reorganization
title_full 2,3,7,8-Tetrachlorodibenzo-p-dioxin influences bovine herpesvirus 1 replication through upregulation of SIRT3 and cytoskeletal reorganization
title_fullStr 2,3,7,8-Tetrachlorodibenzo-p-dioxin influences bovine herpesvirus 1 replication through upregulation of SIRT3 and cytoskeletal reorganization
title_full_unstemmed 2,3,7,8-Tetrachlorodibenzo-p-dioxin influences bovine herpesvirus 1 replication through upregulation of SIRT3 and cytoskeletal reorganization
title_short 2,3,7,8-Tetrachlorodibenzo-p-dioxin influences bovine herpesvirus 1 replication through upregulation of SIRT3 and cytoskeletal reorganization
title_sort 2,3,7,8-tetrachlorodibenzo-p-dioxin influences bovine herpesvirus 1 replication through upregulation of sirt3 and cytoskeletal reorganization
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088714/
https://www.ncbi.nlm.nih.gov/pubmed/29081026
http://dx.doi.org/10.1007/s11259-017-9701-1
work_keys_str_mv AT fioritofilomena 2378tetrachlorodibenzopdioxininfluencesbovineherpesvirus1replicationthroughupregulationofsirt3andcytoskeletalreorganization
AT iovanevalentina 2378tetrachlorodibenzopdioxininfluencesbovineherpesvirus1replicationthroughupregulationofsirt3andcytoskeletalreorganization
AT marulloannarosaria 2378tetrachlorodibenzopdioxininfluencesbovineherpesvirus1replicationthroughupregulationofsirt3andcytoskeletalreorganization
AT costagliolaanna 2378tetrachlorodibenzopdioxininfluencesbovineherpesvirus1replicationthroughupregulationofsirt3andcytoskeletalreorganization
AT granatogiovannaelvira 2378tetrachlorodibenzopdioxininfluencesbovineherpesvirus1replicationthroughupregulationofsirt3andcytoskeletalreorganization
AT demartinoluisa 2378tetrachlorodibenzopdioxininfluencesbovineherpesvirus1replicationthroughupregulationofsirt3andcytoskeletalreorganization

Ejemplares similares