Synthesis and antiviral activity of 18α-glycyrrhizic acid and its esters

New esters (sulfate, nicotinates, and 4-methoxycinnamate) of 18α-glycyrrhizic acid (18α-GA) were synthesized; these were D/E-trans-isomers of natural 18β-GA (GA), which is the major triterpene glycoside in the roots of Spanish licorice and Urals licorice (Glycyrrhiza glabra L. and Gl. uralensis Fish...

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Detalles Bibliográficos
Autores principales: Baltina, L. A., Stolyarova, O. V., Kondratenko, R. M., Plyasunova, O. A., Pokrovskii, A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088723/
https://www.ncbi.nlm.nih.gov/pubmed/32214536
http://dx.doi.org/10.1007/s11094-010-0454-1
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author Baltina, L. A.
Stolyarova, O. V.
Baltina, L. A.
Kondratenko, R. M.
Plyasunova, O. A.
Pokrovskii, A. G.
author_facet Baltina, L. A.
Stolyarova, O. V.
Baltina, L. A.
Kondratenko, R. M.
Plyasunova, O. A.
Pokrovskii, A. G.
author_sort Baltina, L. A.
collection PubMed
description New esters (sulfate, nicotinates, and 4-methoxycinnamate) of 18α-glycyrrhizic acid (18α-GA) were synthesized; these were D/E-trans-isomers of natural 18β-GA (GA), which is the major triterpene glycoside in the roots of Spanish licorice and Urals licorice (Glycyrrhiza glabra L. and Gl. uralensis Fisher). Changes in the stereochemistry of the GA aglycone led to significant decreases in its anti-HIV-1 activity.
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spelling pubmed-70887232020-03-23 Synthesis and antiviral activity of 18α-glycyrrhizic acid and its esters Baltina, L. A. Stolyarova, O. V. Baltina, L. A. Kondratenko, R. M. Plyasunova, O. A. Pokrovskii, A. G. Pharm Chem J Article New esters (sulfate, nicotinates, and 4-methoxycinnamate) of 18α-glycyrrhizic acid (18α-GA) were synthesized; these were D/E-trans-isomers of natural 18β-GA (GA), which is the major triterpene glycoside in the roots of Spanish licorice and Urals licorice (Glycyrrhiza glabra L. and Gl. uralensis Fisher). Changes in the stereochemistry of the GA aglycone led to significant decreases in its anti-HIV-1 activity. Springer US 2010-10-27 2010 /pmc/articles/PMC7088723/ /pubmed/32214536 http://dx.doi.org/10.1007/s11094-010-0454-1 Text en © Springer Science+Business Media, Inc. 2010 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Baltina, L. A.
Stolyarova, O. V.
Baltina, L. A.
Kondratenko, R. M.
Plyasunova, O. A.
Pokrovskii, A. G.
Synthesis and antiviral activity of 18α-glycyrrhizic acid and its esters
title Synthesis and antiviral activity of 18α-glycyrrhizic acid and its esters
title_full Synthesis and antiviral activity of 18α-glycyrrhizic acid and its esters
title_fullStr Synthesis and antiviral activity of 18α-glycyrrhizic acid and its esters
title_full_unstemmed Synthesis and antiviral activity of 18α-glycyrrhizic acid and its esters
title_short Synthesis and antiviral activity of 18α-glycyrrhizic acid and its esters
title_sort synthesis and antiviral activity of 18α-glycyrrhizic acid and its esters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088723/
https://www.ncbi.nlm.nih.gov/pubmed/32214536
http://dx.doi.org/10.1007/s11094-010-0454-1
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