Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters

Glycyrrhizic acid (GA) conjugates with methyl and ethyl esters of D-amino acids (D-Trp, D-Phe, D-Tyr, D-Val, D-Leu) have been synthesized by the activated esters method using mixtures of N-hydroxybenzotriazole or N-hydroxysuccinimide with N,N′-dicyclohexylcarbodiimide. GA conjugate with D-Trp ethyl...

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Autores principales: Fayrushina, A. I., Baltina, L. A., Konovalova, N. I., Petrova, P. A., Eropkin, M. Yu.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088872/
https://www.ncbi.nlm.nih.gov/pubmed/32214781
http://dx.doi.org/10.1134/S1068162017040045
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author Fayrushina, A. I.
Baltina, L. A.
Baltina, L. A.
Konovalova, N. I.
Petrova, P. A.
Eropkin, M. Yu.
author_facet Fayrushina, A. I.
Baltina, L. A.
Baltina, L. A.
Konovalova, N. I.
Petrova, P. A.
Eropkin, M. Yu.
author_sort Fayrushina, A. I.
collection PubMed
description Glycyrrhizic acid (GA) conjugates with methyl and ethyl esters of D-amino acids (D-Trp, D-Phe, D-Tyr, D-Val, D-Leu) have been synthesized by the activated esters method using mixtures of N-hydroxybenzotriazole or N-hydroxysuccinimide with N,N′-dicyclohexylcarbodiimide. GA conjugate with D-Trp ethyl ester exhibited antiviral activity against influenza viruses A/H3N2, A/H1N1/pdm09, A/H5N1, B (SI > 10–29), and HRSV (SI > 25). GA conjugate with D-Trp methyl ester inhibited influenza virus A/H1N1/pdm09 (SI > 30).
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spelling pubmed-70888722020-03-23 Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters Fayrushina, A. I. Baltina, L. A. Baltina, L. A. Konovalova, N. I. Petrova, P. A. Eropkin, M. Yu. Russ J Bioorgan Chem Article Glycyrrhizic acid (GA) conjugates with methyl and ethyl esters of D-amino acids (D-Trp, D-Phe, D-Tyr, D-Val, D-Leu) have been synthesized by the activated esters method using mixtures of N-hydroxybenzotriazole or N-hydroxysuccinimide with N,N′-dicyclohexylcarbodiimide. GA conjugate with D-Trp ethyl ester exhibited antiviral activity against influenza viruses A/H3N2, A/H1N1/pdm09, A/H5N1, B (SI > 10–29), and HRSV (SI > 25). GA conjugate with D-Trp methyl ester inhibited influenza virus A/H1N1/pdm09 (SI > 30). Pleiades Publishing 2017-08-02 2017 /pmc/articles/PMC7088872/ /pubmed/32214781 http://dx.doi.org/10.1134/S1068162017040045 Text en © Pleiades Publishing, Ltd. 2017 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Fayrushina, A. I.
Baltina, L. A.
Baltina, L. A.
Konovalova, N. I.
Petrova, P. A.
Eropkin, M. Yu.
Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters
title Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters
title_full Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters
title_fullStr Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters
title_full_unstemmed Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters
title_short Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters
title_sort synthesis and antiviral activity of novel glycyrrhizic acid conjugates with d-amino acid esters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088872/
https://www.ncbi.nlm.nih.gov/pubmed/32214781
http://dx.doi.org/10.1134/S1068162017040045
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