Clinical study on the related markers of blood coagulation in the patients with ANFH after SARS

The aim of this research was to investigate the blood coagulation function in the patients with avascular necrosis of the femoral head (ANFH) after severe acute respiratory syndrome (SARS). The expression of CD31, CD61, CD62p, CD63 and PAC-1 on platelet membrane was measured respectively by flowcyto...

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Autores principales: Wu, Lianhua, Gao, Chunjin, Wang, Guozhong, Yang, Lin, Hou, Xiaomin, Ge, Huan, Xia, Chengqing, Qi, Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089059/
https://www.ncbi.nlm.nih.gov/pubmed/24573936
http://dx.doi.org/10.1007/s11684-007-0080-9
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author Wu, Lianhua
Gao, Chunjin
Wang, Guozhong
Yang, Lin
Hou, Xiaomin
Ge, Huan
Xia, Chengqing
Qi, Man
author_facet Wu, Lianhua
Gao, Chunjin
Wang, Guozhong
Yang, Lin
Hou, Xiaomin
Ge, Huan
Xia, Chengqing
Qi, Man
author_sort Wu, Lianhua
collection PubMed
description The aim of this research was to investigate the blood coagulation function in the patients with avascular necrosis of the femoral head (ANFH) after severe acute respiratory syndrome (SARS). The expression of CD31, CD61, CD62p, CD63 and PAC-1 on platelet membrane was measured respectively by flowcytometry, and the plasma prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (Fbg) were measured by blood clotting instrument in 26 patients with ANFH after SARS and in 17 healthy adults. The expression of CD31, CD61, CD 62p, CD63 and PAC-1 on platelet membrane in 26 patients was all lower than that in 17 healthy subjects (P < 0.01). The levels of PT, APTT, TT and Fbg in 26 patients were all normal. There is no significant difference (P > 0.05) in those markers between patients and 17 healthy adults. The blood may not be in hypercoagulable state in patients with ANFH after SARS.
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spelling pubmed-70890592020-03-23 Clinical study on the related markers of blood coagulation in the patients with ANFH after SARS Wu, Lianhua Gao, Chunjin Wang, Guozhong Yang, Lin Hou, Xiaomin Ge, Huan Xia, Chengqing Qi, Man Front Med China Research Article The aim of this research was to investigate the blood coagulation function in the patients with avascular necrosis of the femoral head (ANFH) after severe acute respiratory syndrome (SARS). The expression of CD31, CD61, CD62p, CD63 and PAC-1 on platelet membrane was measured respectively by flowcytometry, and the plasma prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (Fbg) were measured by blood clotting instrument in 26 patients with ANFH after SARS and in 17 healthy adults. The expression of CD31, CD61, CD 62p, CD63 and PAC-1 on platelet membrane in 26 patients was all lower than that in 17 healthy subjects (P < 0.01). The levels of PT, APTT, TT and Fbg in 26 patients were all normal. There is no significant difference (P > 0.05) in those markers between patients and 17 healthy adults. The blood may not be in hypercoagulable state in patients with ANFH after SARS. Higher Education Press 2007-10-01 2007 /pmc/articles/PMC7089059/ /pubmed/24573936 http://dx.doi.org/10.1007/s11684-007-0080-9 Text en © Higher Education Press and Springer-Verlag 2007 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Research Article
Wu, Lianhua
Gao, Chunjin
Wang, Guozhong
Yang, Lin
Hou, Xiaomin
Ge, Huan
Xia, Chengqing
Qi, Man
Clinical study on the related markers of blood coagulation in the patients with ANFH after SARS
title Clinical study on the related markers of blood coagulation in the patients with ANFH after SARS
title_full Clinical study on the related markers of blood coagulation in the patients with ANFH after SARS
title_fullStr Clinical study on the related markers of blood coagulation in the patients with ANFH after SARS
title_full_unstemmed Clinical study on the related markers of blood coagulation in the patients with ANFH after SARS
title_short Clinical study on the related markers of blood coagulation in the patients with ANFH after SARS
title_sort clinical study on the related markers of blood coagulation in the patients with anfh after sars
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089059/
https://www.ncbi.nlm.nih.gov/pubmed/24573936
http://dx.doi.org/10.1007/s11684-007-0080-9
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