On the Use of Post-Transcriptional Processing Elements in Transgenes

RNA processing events modulate final productivity of a given transgene. We have evaluated a series of RNA elements for their ability to enhance α1-antitrypsin production in mammary cells. Our results indicate the need for a case-by-case assessment of each construct design and the occurrence of gene...

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Detalles Bibliográficos
Autores principales: Whitelaw, C.B.A., Hiripi, L., Farini, E., Opsahl, M.L., Bosze, Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kluwer Academic Publishers 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089212/
https://www.ncbi.nlm.nih.gov/pubmed/15070078
http://dx.doi.org/10.1023/B:TRAG.0000017178.79427.2c
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author Whitelaw, C.B.A.
Hiripi, L.
Farini, E.
Opsahl, M.L.
Bosze, Z.
author_facet Whitelaw, C.B.A.
Hiripi, L.
Farini, E.
Opsahl, M.L.
Bosze, Z.
author_sort Whitelaw, C.B.A.
collection PubMed
description RNA processing events modulate final productivity of a given transgene. We have evaluated a series of RNA elements for their ability to enhance α1-antitrypsin production in mammary cells. Our results indicate the need for a case-by-case assessment of each construct design and the occurrence of gene silencing events in vivo.
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spelling pubmed-70892122020-03-23 On the Use of Post-Transcriptional Processing Elements in Transgenes Whitelaw, C.B.A. Hiripi, L. Farini, E. Opsahl, M.L. Bosze, Z. Transgenic Res Article RNA processing events modulate final productivity of a given transgene. We have evaluated a series of RNA elements for their ability to enhance α1-antitrypsin production in mammary cells. Our results indicate the need for a case-by-case assessment of each construct design and the occurrence of gene silencing events in vivo. Kluwer Academic Publishers 2004 /pmc/articles/PMC7089212/ /pubmed/15070078 http://dx.doi.org/10.1023/B:TRAG.0000017178.79427.2c Text en © Kluwer Academic Publishers 2004 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Whitelaw, C.B.A.
Hiripi, L.
Farini, E.
Opsahl, M.L.
Bosze, Z.
On the Use of Post-Transcriptional Processing Elements in Transgenes
title On the Use of Post-Transcriptional Processing Elements in Transgenes
title_full On the Use of Post-Transcriptional Processing Elements in Transgenes
title_fullStr On the Use of Post-Transcriptional Processing Elements in Transgenes
title_full_unstemmed On the Use of Post-Transcriptional Processing Elements in Transgenes
title_short On the Use of Post-Transcriptional Processing Elements in Transgenes
title_sort on the use of post-transcriptional processing elements in transgenes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089212/
https://www.ncbi.nlm.nih.gov/pubmed/15070078
http://dx.doi.org/10.1023/B:TRAG.0000017178.79427.2c
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