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Translational Control of the Picornavirus Phenotype

Picornaviruses are small animal viruses with positive-strand genomic RNA, which is translated using cap-independent internal translation initiation. The key role in this is played by ciselements of the 5"-untranslated region (5"-UTR) and, in particular, by the internal ribosome entry site...

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Detalles Bibliográficos
Autor principal: Agol, V. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kluwer Academic Publishers-Plenum Publishers 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089230/
https://www.ncbi.nlm.nih.gov/pubmed/32214465
http://dx.doi.org/10.1023/A:1010531228348
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author Agol, V. I.
author_facet Agol, V. I.
author_sort Agol, V. I.
collection PubMed
description Picornaviruses are small animal viruses with positive-strand genomic RNA, which is translated using cap-independent internal translation initiation. The key role in this is played by ciselements of the 5"-untranslated region (5"-UTR) and, in particular, by the internal ribosome entry site (IRES). The function of translational ciselements requires both canonical translation initiation factors (eIFs) and additional IRES trans-acting factors (ITAFs). All known ITAFs are cell RNA-binding proteins which play a variety of functions in noninfected cells. Specific features of translational ciselements substantially affect the phenotype and, in particular, tissue tropism and pathogenic properties of picornaviruses. It is clear that, in some cases, the molecular mechanism involved is a change in interactions between viral ciselements and ITAFs. The properties and tissue distribution of ITAFs may determine the biological properties of other viruses that also use the IRES-dependent translation initiation. Since this mechanism is also involved in translation of several cell mRNAs, ITAF may contribute to the regulation of the most important aspects of the living activity in noninfected cells.
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spelling pubmed-70892302020-03-23 Translational Control of the Picornavirus Phenotype Agol, V. I. Mol Biol Article Picornaviruses are small animal viruses with positive-strand genomic RNA, which is translated using cap-independent internal translation initiation. The key role in this is played by ciselements of the 5"-untranslated region (5"-UTR) and, in particular, by the internal ribosome entry site (IRES). The function of translational ciselements requires both canonical translation initiation factors (eIFs) and additional IRES trans-acting factors (ITAFs). All known ITAFs are cell RNA-binding proteins which play a variety of functions in noninfected cells. Specific features of translational ciselements substantially affect the phenotype and, in particular, tissue tropism and pathogenic properties of picornaviruses. It is clear that, in some cases, the molecular mechanism involved is a change in interactions between viral ciselements and ITAFs. The properties and tissue distribution of ITAFs may determine the biological properties of other viruses that also use the IRES-dependent translation initiation. Since this mechanism is also involved in translation of several cell mRNAs, ITAF may contribute to the regulation of the most important aspects of the living activity in noninfected cells. Kluwer Academic Publishers-Plenum Publishers 2001 /pmc/articles/PMC7089230/ /pubmed/32214465 http://dx.doi.org/10.1023/A:1010531228348 Text en © MAIK “Nauka/Interperiodica” 2001 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Agol, V. I.
Translational Control of the Picornavirus Phenotype
title Translational Control of the Picornavirus Phenotype
title_full Translational Control of the Picornavirus Phenotype
title_fullStr Translational Control of the Picornavirus Phenotype
title_full_unstemmed Translational Control of the Picornavirus Phenotype
title_short Translational Control of the Picornavirus Phenotype
title_sort translational control of the picornavirus phenotype
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089230/
https://www.ncbi.nlm.nih.gov/pubmed/32214465
http://dx.doi.org/10.1023/A:1010531228348
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