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Viral proteomics: The emerging cutting-edge of virus research

Viruses replicate and proliferate in host cells while continuously adjusting to and modulating the host environment. They encode a wide spectrum of multifunctional proteins, which interplay with and modify proteins in host cells. Viral genomes were chronologically the first to be sequenced. However,...

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Detalles Bibliográficos
Autores principales: Zhou, ShengTao, Liu, Rui, Zhao, Xia, Huang, CanHua, Wei, YuQuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science China Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089374/
https://www.ncbi.nlm.nih.gov/pubmed/21706410
http://dx.doi.org/10.1007/s11427-011-4177-7
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author Zhou, ShengTao
Liu, Rui
Zhao, Xia
Huang, CanHua
Wei, YuQuan
author_facet Zhou, ShengTao
Liu, Rui
Zhao, Xia
Huang, CanHua
Wei, YuQuan
author_sort Zhou, ShengTao
collection PubMed
description Viruses replicate and proliferate in host cells while continuously adjusting to and modulating the host environment. They encode a wide spectrum of multifunctional proteins, which interplay with and modify proteins in host cells. Viral genomes were chronologically the first to be sequenced. However, the corresponding viral proteomes, the alterations of host proteomes upon viral infection, and the dynamic nature of proteins, such as post-translational modifications, enzymatic cleavage, and activation or destruction by proteolysis, remain largely unknown. Emerging high-throughput techniques, in particular quantitative or semi-quantitative mass spectrometry-based proteomics analysis of viral and cellular proteomes, have been applied to define viruses and their interactions with their hosts. Here, we review the major areas of viral proteomics, including virion proteomics, structural proteomics, viral protein interactomics, and changes to the host cell proteome upon viral infection.
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spelling pubmed-70893742020-03-23 Viral proteomics: The emerging cutting-edge of virus research Zhou, ShengTao Liu, Rui Zhao, Xia Huang, CanHua Wei, YuQuan Sci China Life Sci Reviews Viruses replicate and proliferate in host cells while continuously adjusting to and modulating the host environment. They encode a wide spectrum of multifunctional proteins, which interplay with and modify proteins in host cells. Viral genomes were chronologically the first to be sequenced. However, the corresponding viral proteomes, the alterations of host proteomes upon viral infection, and the dynamic nature of proteins, such as post-translational modifications, enzymatic cleavage, and activation or destruction by proteolysis, remain largely unknown. Emerging high-throughput techniques, in particular quantitative or semi-quantitative mass spectrometry-based proteomics analysis of viral and cellular proteomes, have been applied to define viruses and their interactions with their hosts. Here, we review the major areas of viral proteomics, including virion proteomics, structural proteomics, viral protein interactomics, and changes to the host cell proteome upon viral infection. Science China Press 2011-06-26 2011 /pmc/articles/PMC7089374/ /pubmed/21706410 http://dx.doi.org/10.1007/s11427-011-4177-7 Text en © The Author(s) 2011 This article is published under license to BioMed Central Ltd. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited. Open AccessThis is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by-nc/2.0), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Reviews
Zhou, ShengTao
Liu, Rui
Zhao, Xia
Huang, CanHua
Wei, YuQuan
Viral proteomics: The emerging cutting-edge of virus research
title Viral proteomics: The emerging cutting-edge of virus research
title_full Viral proteomics: The emerging cutting-edge of virus research
title_fullStr Viral proteomics: The emerging cutting-edge of virus research
title_full_unstemmed Viral proteomics: The emerging cutting-edge of virus research
title_short Viral proteomics: The emerging cutting-edge of virus research
title_sort viral proteomics: the emerging cutting-edge of virus research
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089374/
https://www.ncbi.nlm.nih.gov/pubmed/21706410
http://dx.doi.org/10.1007/s11427-011-4177-7
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