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Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept
Success in small molecule screening relies heavily on the preselection of compounds. Here, we present a strategy for the enrichment of chemical libraries with potentially bioactive compounds integrating the collected knowledge of medicinal chemistry. Employing a genetic algorithm, substructures typi...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Netherlands
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089384/ https://www.ncbi.nlm.nih.gov/pubmed/19685275 http://dx.doi.org/10.1007/s11030-009-9187-z |