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Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns

The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 brought back memories of the occurrence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. More than 1500 MERS-CoV cases were recorded in 42 months with a case fatality rate (CFR) of 40%. Meanwhile, 80...

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Autores principales: Al-Tawfiq, Jaffar A., Omrani, Ali S., Memish, Ziad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089395/
https://www.ncbi.nlm.nih.gov/pubmed/27146399
http://dx.doi.org/10.1007/s11684-016-0446-y
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author Al-Tawfiq, Jaffar A.
Omrani, Ali S.
Memish, Ziad A.
author_facet Al-Tawfiq, Jaffar A.
Omrani, Ali S.
Memish, Ziad A.
author_sort Al-Tawfiq, Jaffar A.
collection PubMed
description The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 brought back memories of the occurrence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. More than 1500 MERS-CoV cases were recorded in 42 months with a case fatality rate (CFR) of 40%. Meanwhile, 8000 cases of SARS-CoV were confirmed in six months with a CFR of 10%. The clinical presentation of MERS-CoV ranges from mild and non-specific presentation to progressive and severe pneumonia. No predictive signs or symptoms exist to differentiate MERS-CoV from community-acquired pneumonia in hospitalized patients. An apparent heterogeneity was observed in transmission. Most MERS-CoV cases were secondary to large outbreaks in healthcare settings. These cases were secondary to community-acquired cases, which may also cause family outbreaks. Travel-associated MERS infection remains low. However, the virus exhibited a clear tendency to cause large outbreaks outside the Arabian Peninsula as exemplified by the outbreak in the Republic of Korea. In this review, we summarize the current knowledge about MERS-CoV and highlight travel-related issues.
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spelling pubmed-70893952020-03-23 Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns Al-Tawfiq, Jaffar A. Omrani, Ali S. Memish, Ziad A. Front Med Review The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 brought back memories of the occurrence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. More than 1500 MERS-CoV cases were recorded in 42 months with a case fatality rate (CFR) of 40%. Meanwhile, 8000 cases of SARS-CoV were confirmed in six months with a CFR of 10%. The clinical presentation of MERS-CoV ranges from mild and non-specific presentation to progressive and severe pneumonia. No predictive signs or symptoms exist to differentiate MERS-CoV from community-acquired pneumonia in hospitalized patients. An apparent heterogeneity was observed in transmission. Most MERS-CoV cases were secondary to large outbreaks in healthcare settings. These cases were secondary to community-acquired cases, which may also cause family outbreaks. Travel-associated MERS infection remains low. However, the virus exhibited a clear tendency to cause large outbreaks outside the Arabian Peninsula as exemplified by the outbreak in the Republic of Korea. In this review, we summarize the current knowledge about MERS-CoV and highlight travel-related issues. Higher Education Press 2016-05-04 2016 /pmc/articles/PMC7089395/ /pubmed/27146399 http://dx.doi.org/10.1007/s11684-016-0446-y Text en © Higher Education Press and Springer-Verlag Berlin Heidelberg 2016 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Al-Tawfiq, Jaffar A.
Omrani, Ali S.
Memish, Ziad A.
Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns
title Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns
title_full Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns
title_fullStr Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns
title_full_unstemmed Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns
title_short Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns
title_sort middle east respiratory syndrome coronavirus: current situation and travel-associated concerns
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089395/
https://www.ncbi.nlm.nih.gov/pubmed/27146399
http://dx.doi.org/10.1007/s11684-016-0446-y
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