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Review on supermolecules as chemical drugs
Supramolecular medicinal chemistry field has been a quite rapidly developing, increasingly active and newly rising interdiscipline which is the new expansion of supramolecular chemistry in pharmaceutical sciences, and is gradually becoming a relatively independent scientific area. Supramolecular dru...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SP Science in China Press
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089408/ http://dx.doi.org/10.1007/s11426-009-0103-2 |
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author | Zhou, ChengHe Gan, LinLing Zhang, YiYi Zhang, FeiFei Wang, GuangZhou Jin, Lei Geng, RongXia |
author_facet | Zhou, ChengHe Gan, LinLing Zhang, YiYi Zhang, FeiFei Wang, GuangZhou Jin, Lei Geng, RongXia |
author_sort | Zhou, ChengHe |
collection | PubMed |
description | Supramolecular medicinal chemistry field has been a quite rapidly developing, increasingly active and newly rising interdiscipline which is the new expansion of supramolecular chemistry in pharmaceutical sciences, and is gradually becoming a relatively independent scientific area. Supramolecular drugs could be defined as medicinal supermolecules formed by two or more molecules through non-covalent bonds. So far a lot of supermolecules as chemical drugs have been widely used in clinics. Supermolecules as chemical drugs, i.e. supramolecular chemical drugs or supramolecular drugs, which might have the excellences of lower cost, shorter period, higher potential as clinical drugs for their successful research and development, may possess higher bioavailability, better biocompatibility and drug-targeting, fewer multidrug-resistances, lower toxicity, less adverse effect, and better curative effects as well as safety, and therefore exhibit wide potential application. These overwhelming advantages have drawn enormous special attention. This paper gives the definition of supramolecular drugs, proposes the concept of supramolecular chemical drugs, and systematically reviews the recent advances in the research and development of supermolecules, including organic and inorganic complex ones as chemical drugs in the area of antitumor, anti-inflammatory, analgesic, antimalarial, antibacterial, antifungal, antivirus, anti-epileptic, cardiovascular agents and magnetic resonance imaging agents and so on. The perspectives of the foreseeable future and potential application of supramolecules as chemical drugs are also presented. |
format | Online Article Text |
id | pubmed-7089408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | SP Science in China Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-70894082020-03-23 Review on supermolecules as chemical drugs Zhou, ChengHe Gan, LinLing Zhang, YiYi Zhang, FeiFei Wang, GuangZhou Jin, Lei Geng, RongXia Sci China B Chem Article Supramolecular medicinal chemistry field has been a quite rapidly developing, increasingly active and newly rising interdiscipline which is the new expansion of supramolecular chemistry in pharmaceutical sciences, and is gradually becoming a relatively independent scientific area. Supramolecular drugs could be defined as medicinal supermolecules formed by two or more molecules through non-covalent bonds. So far a lot of supermolecules as chemical drugs have been widely used in clinics. Supermolecules as chemical drugs, i.e. supramolecular chemical drugs or supramolecular drugs, which might have the excellences of lower cost, shorter period, higher potential as clinical drugs for their successful research and development, may possess higher bioavailability, better biocompatibility and drug-targeting, fewer multidrug-resistances, lower toxicity, less adverse effect, and better curative effects as well as safety, and therefore exhibit wide potential application. These overwhelming advantages have drawn enormous special attention. This paper gives the definition of supramolecular drugs, proposes the concept of supramolecular chemical drugs, and systematically reviews the recent advances in the research and development of supermolecules, including organic and inorganic complex ones as chemical drugs in the area of antitumor, anti-inflammatory, analgesic, antimalarial, antibacterial, antifungal, antivirus, anti-epileptic, cardiovascular agents and magnetic resonance imaging agents and so on. The perspectives of the foreseeable future and potential application of supramolecules as chemical drugs are also presented. SP Science in China Press 2009-04-16 2009 /pmc/articles/PMC7089408/ http://dx.doi.org/10.1007/s11426-009-0103-2 Text en © Science in China Press and Springer-Verlag GmbH 2009 |
spellingShingle | Article Zhou, ChengHe Gan, LinLing Zhang, YiYi Zhang, FeiFei Wang, GuangZhou Jin, Lei Geng, RongXia Review on supermolecules as chemical drugs |
title | Review on supermolecules as chemical drugs |
title_full | Review on supermolecules as chemical drugs |
title_fullStr | Review on supermolecules as chemical drugs |
title_full_unstemmed | Review on supermolecules as chemical drugs |
title_short | Review on supermolecules as chemical drugs |
title_sort | review on supermolecules as chemical drugs |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089408/ http://dx.doi.org/10.1007/s11426-009-0103-2 |
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