Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses

The synthesis of a new group of triterpenoid acylates has been conducted on the basis of oleanolic, glycyrrhetic, and ursolic acids and betulin. 28-ortho-Methoxycynnamoylbetulin has been demonstrated to possess high activity against the influenza type A (H1N1) virus with the selectivity index SI >...

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Autores principales: Kazakova, O. B., Medvedeva, N. I., Baikova, I. P., Tolstikov, G. A., Lopatina, T. V., Yunusov, M. S., Zaprutko, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP MAIK Nauka/Interperiodica 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089435/
https://www.ncbi.nlm.nih.gov/pubmed/32214780
http://dx.doi.org/10.1134/S1068162010060142
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author Kazakova, O. B.
Medvedeva, N. I.
Baikova, I. P.
Tolstikov, G. A.
Lopatina, T. V.
Yunusov, M. S.
Zaprutko, L.
author_facet Kazakova, O. B.
Medvedeva, N. I.
Baikova, I. P.
Tolstikov, G. A.
Lopatina, T. V.
Yunusov, M. S.
Zaprutko, L.
author_sort Kazakova, O. B.
collection PubMed
description The synthesis of a new group of triterpenoid acylates has been conducted on the basis of oleanolic, glycyrrhetic, and ursolic acids and betulin. 28-ortho-Methoxycynnamoylbetulin has been demonstrated to possess high activity against the influenza type A (H1N1) virus with the selectivity index SI > 100 while studying the activity of the synthesized compounds in relation to the reproduction of viral pathogens of respiratory infections. The high activity of 3,28-dinicotinoylbetulin against the papilloma virus (strain HPV-11) was detected with the selectivity index SI 35.
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spelling pubmed-70894352020-03-23 Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses Kazakova, O. B. Medvedeva, N. I. Baikova, I. P. Tolstikov, G. A. Lopatina, T. V. Yunusov, M. S. Zaprutko, L. Russ J Bioorgan Chem Article The synthesis of a new group of triterpenoid acylates has been conducted on the basis of oleanolic, glycyrrhetic, and ursolic acids and betulin. 28-ortho-Methoxycynnamoylbetulin has been demonstrated to possess high activity against the influenza type A (H1N1) virus with the selectivity index SI > 100 while studying the activity of the synthesized compounds in relation to the reproduction of viral pathogens of respiratory infections. The high activity of 3,28-dinicotinoylbetulin against the papilloma virus (strain HPV-11) was detected with the selectivity index SI 35. SP MAIK Nauka/Interperiodica 2010-11-19 2010 /pmc/articles/PMC7089435/ /pubmed/32214780 http://dx.doi.org/10.1134/S1068162010060142 Text en © Pleiades Publishing, Ltd. 2010 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Kazakova, O. B.
Medvedeva, N. I.
Baikova, I. P.
Tolstikov, G. A.
Lopatina, T. V.
Yunusov, M. S.
Zaprutko, L.
Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses
title Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses
title_full Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses
title_fullStr Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses
title_full_unstemmed Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses
title_short Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses
title_sort synthesis of triterpenoid acylates: effective reproduction inhibitors of influenza a (h1n1) and papilloma viruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089435/
https://www.ncbi.nlm.nih.gov/pubmed/32214780
http://dx.doi.org/10.1134/S1068162010060142
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