IFNL4 polymorphism as a predictor of chronic hepatitis C treatment efficiency in Ukrainian patients

The aim of this study was to examine association between IFNL4 gene ss469415590 and treatment efficiency in group of Ukrainian PEG-interferon/ribavirin-treated chronic hepatitis C patients. Study group consisted of 92 unrelated hepatitis C virus genotype 1 mono-infected patients: case group–29 patie...

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Detalles Bibliográficos
Autores principales: Kucherenko, A. M., Pampukha, V. M., Romanchuk, K. Yu., Chernushyn, S. Yu., Bobrova, I. A., Moroz, L. V., Livshits, L. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Allerton Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089495/
https://www.ncbi.nlm.nih.gov/pubmed/32214544
http://dx.doi.org/10.3103/S0095452716050066
Descripción
Sumario:The aim of this study was to examine association between IFNL4 gene ss469415590 and treatment efficiency in group of Ukrainian PEG-interferon/ribavirin-treated chronic hepatitis C patients. Study group consisted of 92 unrelated hepatitis C virus genotype 1 mono-infected patients: case group–29 patients with late or absent virological response; control group–63 patients with sustained virological response. Study material was genomic DNA. Genotyping was performed using amplification-refractory mutation system PCR. Statistical analysis was performed using GenePop and OpenEpi statistical packages. Obtained results show that ss469415590 ΔG/ΔG genotype is associated with poor virological response (OR = 3.62; CI 95%: 1.12–11.67) in PEG-interferon/ribavirin-treated chronic hepatitis C patients from Ukraine.

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