IFNL4 polymorphism as a predictor of chronic hepatitis C treatment efficiency in Ukrainian patients

The aim of this study was to examine association between IFNL4 gene ss469415590 and treatment efficiency in group of Ukrainian PEG-interferon/ribavirin-treated chronic hepatitis C patients. Study group consisted of 92 unrelated hepatitis C virus genotype 1 mono-infected patients: case group–29 patie...

Descripción completa

Detalles Bibliográficos
Autores principales: Kucherenko, A. M., Pampukha, V. M., Romanchuk, K. Yu., Chernushyn, S. Yu., Bobrova, I. A., Moroz, L. V., Livshits, L. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Allerton Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089495/
https://www.ncbi.nlm.nih.gov/pubmed/32214544
http://dx.doi.org/10.3103/S0095452716050066
_version_ 1783509748931362816
author Kucherenko, A. M.
Pampukha, V. M.
Romanchuk, K. Yu.
Chernushyn, S. Yu.
Bobrova, I. A.
Moroz, L. V.
Livshits, L. A.
author_facet Kucherenko, A. M.
Pampukha, V. M.
Romanchuk, K. Yu.
Chernushyn, S. Yu.
Bobrova, I. A.
Moroz, L. V.
Livshits, L. A.
author_sort Kucherenko, A. M.
collection PubMed
description The aim of this study was to examine association between IFNL4 gene ss469415590 and treatment efficiency in group of Ukrainian PEG-interferon/ribavirin-treated chronic hepatitis C patients. Study group consisted of 92 unrelated hepatitis C virus genotype 1 mono-infected patients: case group–29 patients with late or absent virological response; control group–63 patients with sustained virological response. Study material was genomic DNA. Genotyping was performed using amplification-refractory mutation system PCR. Statistical analysis was performed using GenePop and OpenEpi statistical packages. Obtained results show that ss469415590 ΔG/ΔG genotype is associated with poor virological response (OR = 3.62; CI 95%: 1.12–11.67) in PEG-interferon/ribavirin-treated chronic hepatitis C patients from Ukraine.
format Online
Article
Text
id pubmed-7089495
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Allerton Press
record_format MEDLINE/PubMed
spelling pubmed-70894952020-03-23 IFNL4 polymorphism as a predictor of chronic hepatitis C treatment efficiency in Ukrainian patients Kucherenko, A. M. Pampukha, V. M. Romanchuk, K. Yu. Chernushyn, S. Yu. Bobrova, I. A. Moroz, L. V. Livshits, L. A. Cytol. Genet Article The aim of this study was to examine association between IFNL4 gene ss469415590 and treatment efficiency in group of Ukrainian PEG-interferon/ribavirin-treated chronic hepatitis C patients. Study group consisted of 92 unrelated hepatitis C virus genotype 1 mono-infected patients: case group–29 patients with late or absent virological response; control group–63 patients with sustained virological response. Study material was genomic DNA. Genotyping was performed using amplification-refractory mutation system PCR. Statistical analysis was performed using GenePop and OpenEpi statistical packages. Obtained results show that ss469415590 ΔG/ΔG genotype is associated with poor virological response (OR = 3.62; CI 95%: 1.12–11.67) in PEG-interferon/ribavirin-treated chronic hepatitis C patients from Ukraine. Allerton Press 2016-10-11 2016 /pmc/articles/PMC7089495/ /pubmed/32214544 http://dx.doi.org/10.3103/S0095452716050066 Text en © Allerton Press, Inc. 2016 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Kucherenko, A. M.
Pampukha, V. M.
Romanchuk, K. Yu.
Chernushyn, S. Yu.
Bobrova, I. A.
Moroz, L. V.
Livshits, L. A.
IFNL4 polymorphism as a predictor of chronic hepatitis C treatment efficiency in Ukrainian patients
title IFNL4 polymorphism as a predictor of chronic hepatitis C treatment efficiency in Ukrainian patients
title_full IFNL4 polymorphism as a predictor of chronic hepatitis C treatment efficiency in Ukrainian patients
title_fullStr IFNL4 polymorphism as a predictor of chronic hepatitis C treatment efficiency in Ukrainian patients
title_full_unstemmed IFNL4 polymorphism as a predictor of chronic hepatitis C treatment efficiency in Ukrainian patients
title_short IFNL4 polymorphism as a predictor of chronic hepatitis C treatment efficiency in Ukrainian patients
title_sort ifnl4 polymorphism as a predictor of chronic hepatitis c treatment efficiency in ukrainian patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089495/
https://www.ncbi.nlm.nih.gov/pubmed/32214544
http://dx.doi.org/10.3103/S0095452716050066
work_keys_str_mv AT kucherenkoam ifnl4polymorphismasapredictorofchronichepatitisctreatmentefficiencyinukrainianpatients
AT pampukhavm ifnl4polymorphismasapredictorofchronichepatitisctreatmentefficiencyinukrainianpatients
AT romanchukkyu ifnl4polymorphismasapredictorofchronichepatitisctreatmentefficiencyinukrainianpatients
AT chernushynsyu ifnl4polymorphismasapredictorofchronichepatitisctreatmentefficiencyinukrainianpatients
AT bobrovaia ifnl4polymorphismasapredictorofchronichepatitisctreatmentefficiencyinukrainianpatients
AT morozlv ifnl4polymorphismasapredictorofchronichepatitisctreatmentefficiencyinukrainianpatients
AT livshitsla ifnl4polymorphismasapredictorofchronichepatitisctreatmentefficiencyinukrainianpatients

Ejemplares similares