Cross-linked Small Polyethylenimines: While Still Nontoxic, Deliver DNA Efficiently to Mammalian Cells in Vitro and in Vivo

PURPOSE. Polyethylenimine (PEI) is among the most efficient nonviral gene delivery vectors. Its efficiency and cytotoxicity depend on molecular weight, with the 25-kDa PEI being most efficient but cytotoxic. Smaller PEIs are noncytotoxic but less efficient. Enhancement in gene delivery efficiency wi...

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Detalles Bibliográficos
Autores principales: Thomas, Mini, Ge, Qing, Lu, James J., Chen, Jianzhu, Klibanov, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kluwer Academic Publishers-Plenum Publishers 2005
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089549/
https://www.ncbi.nlm.nih.gov/pubmed/15835742
http://dx.doi.org/10.1007/s11095-004-1874-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089549/
https://www.ncbi.nlm.nih.gov/pubmed/15835742
http://dx.doi.org/10.1007/s11095-004-1874-y

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