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Tumor Location and Treatment Modality are Associated with Overall Survival in Adult Medulloblastoma
Introduction Medulloblastoma (MB) is an aggressive brain tumor most commonly found in children. Although prognostic factors are well studied in children, factors affecting survival in adults with medulloblastoma are unclear. Methods We queried the 1973-2015 United States Surveillance, Epidemiology,...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089624/ https://www.ncbi.nlm.nih.gov/pubmed/32226663 http://dx.doi.org/10.7759/cureus.7061 |
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author | Ma, Anthony K Freedman, Isaac Lee, Jun Hui Miyagishima, Danielle Ahmed, Osama Yeung, Jacky |
author_facet | Ma, Anthony K Freedman, Isaac Lee, Jun Hui Miyagishima, Danielle Ahmed, Osama Yeung, Jacky |
author_sort | Ma, Anthony K |
collection | PubMed |
description | Introduction Medulloblastoma (MB) is an aggressive brain tumor most commonly found in children. Although prognostic factors are well studied in children, factors affecting survival in adults with medulloblastoma are unclear. Methods We queried the 1973-2015 United States Surveillance, Epidemiology, and End Results (SEER) registry to identify all adult cases of medulloblastoma, and performed multivariate survival analyses to assess the relationships amongst various clinical variables, including age, sex, race, tumor location, treatment modalities, and overall survival. Results A total of 857 patients, 20 years of age and older, with MB were identified in the SEER registry. Adult cases presented most frequently in the cerebellum (91.6%) compared to other less common regions (brain stem 3.2%, brain 2.2%, ventricle 1.8%). The overall median survival for adult MB is 60 months (SD = 94.3) and survival time is related to tumor location and course of treatment (P < 0.001). Multivariate Cox proportional hazard models showed that lesions found outside the cerebellum corresponded to worse median survival times (37 months) than those in the cerebellum (63 months) (hazard ratio 1.69, 95% CI 1.321-2.158, P = 0.001). Patients who were assigned chemotherapy had shorter survival (54 months) than those who were not (67 months) (HR 1.4515, 95% CI 1.26-1.671, P < 0.001), but receiving radiation therapy was associated with better overall survival (66 months) relative to not receiving radiation (25 months) (HR 0.581, 95% CI 0.48-0.70, P < 0.001). Conclusions Tumor location appears to be a significant prognostic factor for survival in adult MB. Recommended treatment regimes, likely reflective of the underlying aggressiveness of the tumor, also seem to impact survival. |
format | Online Article Text |
id | pubmed-7089624 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-70896242020-03-27 Tumor Location and Treatment Modality are Associated with Overall Survival in Adult Medulloblastoma Ma, Anthony K Freedman, Isaac Lee, Jun Hui Miyagishima, Danielle Ahmed, Osama Yeung, Jacky Cureus Radiation Oncology Introduction Medulloblastoma (MB) is an aggressive brain tumor most commonly found in children. Although prognostic factors are well studied in children, factors affecting survival in adults with medulloblastoma are unclear. Methods We queried the 1973-2015 United States Surveillance, Epidemiology, and End Results (SEER) registry to identify all adult cases of medulloblastoma, and performed multivariate survival analyses to assess the relationships amongst various clinical variables, including age, sex, race, tumor location, treatment modalities, and overall survival. Results A total of 857 patients, 20 years of age and older, with MB were identified in the SEER registry. Adult cases presented most frequently in the cerebellum (91.6%) compared to other less common regions (brain stem 3.2%, brain 2.2%, ventricle 1.8%). The overall median survival for adult MB is 60 months (SD = 94.3) and survival time is related to tumor location and course of treatment (P < 0.001). Multivariate Cox proportional hazard models showed that lesions found outside the cerebellum corresponded to worse median survival times (37 months) than those in the cerebellum (63 months) (hazard ratio 1.69, 95% CI 1.321-2.158, P = 0.001). Patients who were assigned chemotherapy had shorter survival (54 months) than those who were not (67 months) (HR 1.4515, 95% CI 1.26-1.671, P < 0.001), but receiving radiation therapy was associated with better overall survival (66 months) relative to not receiving radiation (25 months) (HR 0.581, 95% CI 0.48-0.70, P < 0.001). Conclusions Tumor location appears to be a significant prognostic factor for survival in adult MB. Recommended treatment regimes, likely reflective of the underlying aggressiveness of the tumor, also seem to impact survival. Cureus 2020-02-20 /pmc/articles/PMC7089624/ /pubmed/32226663 http://dx.doi.org/10.7759/cureus.7061 Text en Copyright © 2020, Ma et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Radiation Oncology Ma, Anthony K Freedman, Isaac Lee, Jun Hui Miyagishima, Danielle Ahmed, Osama Yeung, Jacky Tumor Location and Treatment Modality are Associated with Overall Survival in Adult Medulloblastoma |
title | Tumor Location and Treatment Modality are Associated with Overall Survival in Adult Medulloblastoma |
title_full | Tumor Location and Treatment Modality are Associated with Overall Survival in Adult Medulloblastoma |
title_fullStr | Tumor Location and Treatment Modality are Associated with Overall Survival in Adult Medulloblastoma |
title_full_unstemmed | Tumor Location and Treatment Modality are Associated with Overall Survival in Adult Medulloblastoma |
title_short | Tumor Location and Treatment Modality are Associated with Overall Survival in Adult Medulloblastoma |
title_sort | tumor location and treatment modality are associated with overall survival in adult medulloblastoma |
topic | Radiation Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089624/ https://www.ncbi.nlm.nih.gov/pubmed/32226663 http://dx.doi.org/10.7759/cureus.7061 |
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