Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics

Peptidyl-prolyl isomerase (PIN1) specifically binds and isomerizes the phosphorylated serine/threonine–proline (pSer/Thr–Pro) motif, which results in the alteration of protein structure, function, and stability. The altered structure and function of these phosphorylated proteins regulated by PIN1 ar...

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Autores principales: Yu, Ji Hoon, Im, Chun Young, Min, Sang-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089927/
https://www.ncbi.nlm.nih.gov/pubmed/32258027
http://dx.doi.org/10.3389/fcell.2020.00120
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author Yu, Ji Hoon
Im, Chun Young
Min, Sang-Hyun
author_facet Yu, Ji Hoon
Im, Chun Young
Min, Sang-Hyun
author_sort Yu, Ji Hoon
collection PubMed
description Peptidyl-prolyl isomerase (PIN1) specifically binds and isomerizes the phosphorylated serine/threonine–proline (pSer/Thr–Pro) motif, which results in the alteration of protein structure, function, and stability. The altered structure and function of these phosphorylated proteins regulated by PIN1 are closely related to cancer development. PIN1 is highly expressed in human cancers and promotes cancer as well as cancer stem cells by breaking the balance of oncogenes and tumor suppressors. In this review, we discuss the roles of PIN1 in cancer and PIN1-targeted small-molecule compounds.
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spelling pubmed-70899272020-03-31 Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics Yu, Ji Hoon Im, Chun Young Min, Sang-Hyun Front Cell Dev Biol Cell and Developmental Biology Peptidyl-prolyl isomerase (PIN1) specifically binds and isomerizes the phosphorylated serine/threonine–proline (pSer/Thr–Pro) motif, which results in the alteration of protein structure, function, and stability. The altered structure and function of these phosphorylated proteins regulated by PIN1 are closely related to cancer development. PIN1 is highly expressed in human cancers and promotes cancer as well as cancer stem cells by breaking the balance of oncogenes and tumor suppressors. In this review, we discuss the roles of PIN1 in cancer and PIN1-targeted small-molecule compounds. Frontiers Media S.A. 2020-03-17 /pmc/articles/PMC7089927/ /pubmed/32258027 http://dx.doi.org/10.3389/fcell.2020.00120 Text en Copyright © 2020 Yu, Im and Min. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Yu, Ji Hoon
Im, Chun Young
Min, Sang-Hyun
Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics
title Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics
title_full Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics
title_fullStr Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics
title_full_unstemmed Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics
title_short Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics
title_sort function of pin1 in cancer development and its inhibitors as cancer therapeutics
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089927/
https://www.ncbi.nlm.nih.gov/pubmed/32258027
http://dx.doi.org/10.3389/fcell.2020.00120
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