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PD-1-Mediated PI3K/Akt/mTOR, Caspase 9/Caspase 3 and ERK Pathways Are Involved in Regulating the Apoptosis and Proliferation of CD4(+) and CD8(+) T Cells During BVDV Infection in vitro

Acute infection of bovine viral diarrhea virus (BVDV) is associated with immune dysfunction and can cause peripheral blood lymphopenia and lymphocyte apoptosis. Our previous study has confirmed that programmed death-1 (PD-1) blockade inhibits peripheral blood lymphocyte (PBL) apoptosis and restores...

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Detalles Bibliográficos
Autores principales:	Liu, Yu, Liu, Shanshan, Wu, Chenhua, Huang, Wenjing, Xu, Bin, Lian, Shuai, Wang, Li, Yue, Shan, Chen, Nannan, Zhu, Zhanbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089960/ https://www.ncbi.nlm.nih.gov/pubmed/32256500 http://dx.doi.org/10.3389/fimmu.2020.00467

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