Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease

Leptin stimulates the sympathetic nervous system (SNS), energy expenditure, and weight loss; however, the underlying molecular mechanism remains elusive. Here, we uncover Sh2b1 in leptin receptor (LepR) neurons as a critical component of a SNS/brown adipose tissue (BAT)/thermogenesis axis. LepR neur...

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Detalles Bibliográficos
Autores principales: Jiang, Lin, Su, Haoran, Wu, Xiaoyin, Shen, Hong, Kim, Min-Hyun, Li, Yuan, Myers, Martin G., Owyang, Chung, Rui, Liangyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089966/
https://www.ncbi.nlm.nih.gov/pubmed/32251290
http://dx.doi.org/10.1038/s41467-020-15328-3

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