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Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India
Identification of the causes of poor oral vaccine immunogenicity in low-income countries might lead to more effective vaccines. We measured mucosal and systemic immune parameters at the time of vaccination with oral poliovirus vaccine (OPV) in 292 Indian infants aged 6–11 months, including plasma cy...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089977/ https://www.ncbi.nlm.nih.gov/pubmed/32218999 http://dx.doi.org/10.1038/s41541-020-0178-5 |
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author | Babji, Sudhir Manickavasagam, Punithavathy Chen, Yin-Huai Jeyavelu, Nithya Jose, Nisha Vincy Praharaj, Ira Syed, Chanduni Kaliappan, Saravanakumar Puthupalayam John, Jacob Giri, Sidhartha Venugopal, Srinivasan Kampmann, Beate Parker, Edward P. K. Iturriza-Gómara, Miren Kang, Gagandeep Grassly, Nicholas C. Uhlig, Holm H. |
author_facet | Babji, Sudhir Manickavasagam, Punithavathy Chen, Yin-Huai Jeyavelu, Nithya Jose, Nisha Vincy Praharaj, Ira Syed, Chanduni Kaliappan, Saravanakumar Puthupalayam John, Jacob Giri, Sidhartha Venugopal, Srinivasan Kampmann, Beate Parker, Edward P. K. Iturriza-Gómara, Miren Kang, Gagandeep Grassly, Nicholas C. Uhlig, Holm H. |
author_sort | Babji, Sudhir |
collection | PubMed |
description | Identification of the causes of poor oral vaccine immunogenicity in low-income countries might lead to more effective vaccines. We measured mucosal and systemic immune parameters at the time of vaccination with oral poliovirus vaccine (OPV) in 292 Indian infants aged 6–11 months, including plasma cytokines, leukocyte counts, fecal biomarkers of environmental enteropathy and peripheral blood T-cell phenotype, focused on gut-homing regulatory CD4+ populations. We did not find a distinct immune phenotype associated with OPV immunogenicity, although viral pathogens were more prevalent in stool at the time of immunization among infants who failed to seroconvert (63.9% vs. 45.6%, p = 0.002). Using a machine-learning approach, we could predict seroconversion a priori using immune parameters and infection status with a median 58% accuracy (cross-validation IQR: 50–69%) compared with 50% expected by chance. Better identification of immune predictors of OPV immunogenicity is likely to require sampling of mucosal tissue and improved oral poliovirus infection models. |
format | Online Article Text |
id | pubmed-7089977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70899772020-03-26 Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India Babji, Sudhir Manickavasagam, Punithavathy Chen, Yin-Huai Jeyavelu, Nithya Jose, Nisha Vincy Praharaj, Ira Syed, Chanduni Kaliappan, Saravanakumar Puthupalayam John, Jacob Giri, Sidhartha Venugopal, Srinivasan Kampmann, Beate Parker, Edward P. K. Iturriza-Gómara, Miren Kang, Gagandeep Grassly, Nicholas C. Uhlig, Holm H. NPJ Vaccines Article Identification of the causes of poor oral vaccine immunogenicity in low-income countries might lead to more effective vaccines. We measured mucosal and systemic immune parameters at the time of vaccination with oral poliovirus vaccine (OPV) in 292 Indian infants aged 6–11 months, including plasma cytokines, leukocyte counts, fecal biomarkers of environmental enteropathy and peripheral blood T-cell phenotype, focused on gut-homing regulatory CD4+ populations. We did not find a distinct immune phenotype associated with OPV immunogenicity, although viral pathogens were more prevalent in stool at the time of immunization among infants who failed to seroconvert (63.9% vs. 45.6%, p = 0.002). Using a machine-learning approach, we could predict seroconversion a priori using immune parameters and infection status with a median 58% accuracy (cross-validation IQR: 50–69%) compared with 50% expected by chance. Better identification of immune predictors of OPV immunogenicity is likely to require sampling of mucosal tissue and improved oral poliovirus infection models. Nature Publishing Group UK 2020-03-23 /pmc/articles/PMC7089977/ /pubmed/32218999 http://dx.doi.org/10.1038/s41541-020-0178-5 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Babji, Sudhir Manickavasagam, Punithavathy Chen, Yin-Huai Jeyavelu, Nithya Jose, Nisha Vincy Praharaj, Ira Syed, Chanduni Kaliappan, Saravanakumar Puthupalayam John, Jacob Giri, Sidhartha Venugopal, Srinivasan Kampmann, Beate Parker, Edward P. K. Iturriza-Gómara, Miren Kang, Gagandeep Grassly, Nicholas C. Uhlig, Holm H. Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India |
title | Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India |
title_full | Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India |
title_fullStr | Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India |
title_full_unstemmed | Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India |
title_short | Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India |
title_sort | immune predictors of oral poliovirus vaccine immunogenicity among infants in south india |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089977/ https://www.ncbi.nlm.nih.gov/pubmed/32218999 http://dx.doi.org/10.1038/s41541-020-0178-5 |
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