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Locating neural transfer effects of n-back training on the central executive: a longitudinal fMRI study

The large number of behavioral studies testing whether working memory training improves performance on an untrained task have yielded inconclusive results. Moreover, some studies have investigated the possible neural changes during the performance of untrained tasks after training. Here, we studied...

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Autores principales: Miró-Padilla, Anna, Bueichekú, Elisenda, Ávila, César
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089996/
https://www.ncbi.nlm.nih.gov/pubmed/32251354
http://dx.doi.org/10.1038/s41598-020-62067-y
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author Miró-Padilla, Anna
Bueichekú, Elisenda
Ávila, César
author_facet Miró-Padilla, Anna
Bueichekú, Elisenda
Ávila, César
author_sort Miró-Padilla, Anna
collection PubMed
description The large number of behavioral studies testing whether working memory training improves performance on an untrained task have yielded inconclusive results. Moreover, some studies have investigated the possible neural changes during the performance of untrained tasks after training. Here, we studied the transfer from n-back training to the Paced Auditory Serial Addition Test (PASAT), two different tasks that use the central executive system to maintain verbal stimuli. Participants completed fMRI sessions at baseline, immediately after one week of training, and at the five-week follow-up. Although behavioral transfer effects were not obtained, training was associated with decreased activation in the anterior dorsolateral prefrontal cortex (DLPFC; BA 9/46) while performing the PASAT that remained stable five weeks later. Consistent with our hypothesis, the changes in the anterior DLFPC largely overlapped with the n-back task fMRI activations. In conclusion, working memory training improves efficiency in brain areas involved in the trained task that may affect untrained tasks, specifically in brain areas responsible for the same cognitive processes.
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spelling pubmed-70899962020-03-26 Locating neural transfer effects of n-back training on the central executive: a longitudinal fMRI study Miró-Padilla, Anna Bueichekú, Elisenda Ávila, César Sci Rep Article The large number of behavioral studies testing whether working memory training improves performance on an untrained task have yielded inconclusive results. Moreover, some studies have investigated the possible neural changes during the performance of untrained tasks after training. Here, we studied the transfer from n-back training to the Paced Auditory Serial Addition Test (PASAT), two different tasks that use the central executive system to maintain verbal stimuli. Participants completed fMRI sessions at baseline, immediately after one week of training, and at the five-week follow-up. Although behavioral transfer effects were not obtained, training was associated with decreased activation in the anterior dorsolateral prefrontal cortex (DLPFC; BA 9/46) while performing the PASAT that remained stable five weeks later. Consistent with our hypothesis, the changes in the anterior DLFPC largely overlapped with the n-back task fMRI activations. In conclusion, working memory training improves efficiency in brain areas involved in the trained task that may affect untrained tasks, specifically in brain areas responsible for the same cognitive processes. Nature Publishing Group UK 2020-03-23 /pmc/articles/PMC7089996/ /pubmed/32251354 http://dx.doi.org/10.1038/s41598-020-62067-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Miró-Padilla, Anna
Bueichekú, Elisenda
Ávila, César
Locating neural transfer effects of n-back training on the central executive: a longitudinal fMRI study
title Locating neural transfer effects of n-back training on the central executive: a longitudinal fMRI study
title_full Locating neural transfer effects of n-back training on the central executive: a longitudinal fMRI study
title_fullStr Locating neural transfer effects of n-back training on the central executive: a longitudinal fMRI study
title_full_unstemmed Locating neural transfer effects of n-back training on the central executive: a longitudinal fMRI study
title_short Locating neural transfer effects of n-back training on the central executive: a longitudinal fMRI study
title_sort locating neural transfer effects of n-back training on the central executive: a longitudinal fmri study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089996/
https://www.ncbi.nlm.nih.gov/pubmed/32251354
http://dx.doi.org/10.1038/s41598-020-62067-y
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