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Study on the Relationship Between Respiratory Distress Syndrome and SP-A1 (rs1059057) Gene Polymorphism in Mongolian Very Premature Infants

Aim: To study the relationship between rs1059057 polymorphism of pulmonary surfactant protein A1 (SP-A1) and respiratory distress syndrome (RDS) in Mongolian very premature infants. Methods: Applying the strategy of case-control study, 120 Mongolian RDS very premature infants (58 males and 62 female...

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Autores principales: Wang, Xiaoli, Zhang, Yuheng, Mei, Hua, An, Caiyan, Liu, Chunzhi, Zhang, Yayu, Zhang, Yanbo, Xin, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090089/
https://www.ncbi.nlm.nih.gov/pubmed/32257981
http://dx.doi.org/10.3389/fped.2020.00081
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author Wang, Xiaoli
Zhang, Yuheng
Mei, Hua
An, Caiyan
Liu, Chunzhi
Zhang, Yayu
Zhang, Yanbo
Xin, Chun
author_facet Wang, Xiaoli
Zhang, Yuheng
Mei, Hua
An, Caiyan
Liu, Chunzhi
Zhang, Yayu
Zhang, Yanbo
Xin, Chun
author_sort Wang, Xiaoli
collection PubMed
description Aim: To study the relationship between rs1059057 polymorphism of pulmonary surfactant protein A1 (SP-A1) and respiratory distress syndrome (RDS) in Mongolian very premature infants. Methods: Applying the strategy of case-control study, 120 Mongolian RDS very premature infants (58 males and 62 females) in the western part of Inner Mongolia were selected as the case group, and 120 subjects of non-RDS very premature infants (56 males and 64 females) with the same nationality, same sex and similar gestational age were used as the control group. The single nucleotide polymorphism (SNP) site rs1059057 of SP-A1 was genotyped using polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP). Results: Two genotypes, A/G and A/A, were detected at the SP-A1 rs1059057 locus in the western part of Inner Mongolia. In the case group, the frequencies of two genotypes were 53 and 47%, and the frequencies of A allele and G allele were 73 and 27%, respectively. In the control group, the frequencies of the two genotypes were 42 and 58%, and the frequencies of A allele and G allele were 79 and 21%, respectively. There was no significant difference in the genotype frequency of SP-A1 (rs1059057) locus between the case group and the control group (X(2) = 3.275, P > 0.05), and no significant difference in allele frequency between the case group and the control group (X(2) = 2.255, P > 0.05). Conclusion: The genotypes and allele frequencies of SP-A1 (rs1059057) locus were not associated with the incidence of RDS in Mongolian very premature infants in western Inner Mongolia.
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spelling pubmed-70900892020-03-31 Study on the Relationship Between Respiratory Distress Syndrome and SP-A1 (rs1059057) Gene Polymorphism in Mongolian Very Premature Infants Wang, Xiaoli Zhang, Yuheng Mei, Hua An, Caiyan Liu, Chunzhi Zhang, Yayu Zhang, Yanbo Xin, Chun Front Pediatr Pediatrics Aim: To study the relationship between rs1059057 polymorphism of pulmonary surfactant protein A1 (SP-A1) and respiratory distress syndrome (RDS) in Mongolian very premature infants. Methods: Applying the strategy of case-control study, 120 Mongolian RDS very premature infants (58 males and 62 females) in the western part of Inner Mongolia were selected as the case group, and 120 subjects of non-RDS very premature infants (56 males and 64 females) with the same nationality, same sex and similar gestational age were used as the control group. The single nucleotide polymorphism (SNP) site rs1059057 of SP-A1 was genotyped using polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP). Results: Two genotypes, A/G and A/A, were detected at the SP-A1 rs1059057 locus in the western part of Inner Mongolia. In the case group, the frequencies of two genotypes were 53 and 47%, and the frequencies of A allele and G allele were 73 and 27%, respectively. In the control group, the frequencies of the two genotypes were 42 and 58%, and the frequencies of A allele and G allele were 79 and 21%, respectively. There was no significant difference in the genotype frequency of SP-A1 (rs1059057) locus between the case group and the control group (X(2) = 3.275, P > 0.05), and no significant difference in allele frequency between the case group and the control group (X(2) = 2.255, P > 0.05). Conclusion: The genotypes and allele frequencies of SP-A1 (rs1059057) locus were not associated with the incidence of RDS in Mongolian very premature infants in western Inner Mongolia. Frontiers Media S.A. 2020-03-17 /pmc/articles/PMC7090089/ /pubmed/32257981 http://dx.doi.org/10.3389/fped.2020.00081 Text en Copyright © 2020 Wang, Zhang, Mei, An, Liu, Zhang, Zhang and Xin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Wang, Xiaoli
Zhang, Yuheng
Mei, Hua
An, Caiyan
Liu, Chunzhi
Zhang, Yayu
Zhang, Yanbo
Xin, Chun
Study on the Relationship Between Respiratory Distress Syndrome and SP-A1 (rs1059057) Gene Polymorphism in Mongolian Very Premature Infants
title Study on the Relationship Between Respiratory Distress Syndrome and SP-A1 (rs1059057) Gene Polymorphism in Mongolian Very Premature Infants
title_full Study on the Relationship Between Respiratory Distress Syndrome and SP-A1 (rs1059057) Gene Polymorphism in Mongolian Very Premature Infants
title_fullStr Study on the Relationship Between Respiratory Distress Syndrome and SP-A1 (rs1059057) Gene Polymorphism in Mongolian Very Premature Infants
title_full_unstemmed Study on the Relationship Between Respiratory Distress Syndrome and SP-A1 (rs1059057) Gene Polymorphism in Mongolian Very Premature Infants
title_short Study on the Relationship Between Respiratory Distress Syndrome and SP-A1 (rs1059057) Gene Polymorphism in Mongolian Very Premature Infants
title_sort study on the relationship between respiratory distress syndrome and sp-a1 (rs1059057) gene polymorphism in mongolian very premature infants
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090089/
https://www.ncbi.nlm.nih.gov/pubmed/32257981
http://dx.doi.org/10.3389/fped.2020.00081
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