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Longitudinal Changes in Whole-Brain Functional Connectivity Strength Patterns and the Relationship With the Global Cognitive Decline in Older Adults
Aging is associated with changes in brain functional patterns as well as cognition. The present research sought to investigate longitudinal changes in whole brain functional connectivity strength (FCS) and cognitive performance scores in very old cognitively unimpaired individuals. We studied 34 cog...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090100/ https://www.ncbi.nlm.nih.gov/pubmed/32256339 http://dx.doi.org/10.3389/fnagi.2020.00071 |
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author | Li, Qiongge Dong, Chao Liu, Tao Chen, Xiaodan Perry, Alistair Jiang, Jiyang Cheng, Jian Niu, Haijun Kochan, Nicole A. Brodaty, Henry Sachdev, Perminder S. Wen, Wei |
author_facet | Li, Qiongge Dong, Chao Liu, Tao Chen, Xiaodan Perry, Alistair Jiang, Jiyang Cheng, Jian Niu, Haijun Kochan, Nicole A. Brodaty, Henry Sachdev, Perminder S. Wen, Wei |
author_sort | Li, Qiongge |
collection | PubMed |
description | Aging is associated with changes in brain functional patterns as well as cognition. The present research sought to investigate longitudinal changes in whole brain functional connectivity strength (FCS) and cognitive performance scores in very old cognitively unimpaired individuals. We studied 34 cognitively normal elderly individuals at both baseline and 4-year follow-up (baseline age = 78 ± 3.14 years) with resting-state functional magnetic resonance imaging (r-fMRI), structural MRI scans, and neuropsychological assessments conducted. Voxel-based whole brain FCS was calculated and we found that bilateral superior parietal and medial frontal regions showed decreased FCS, while the supplementary motor area (SMA) and insula showed increased FCS with age, along with a decrease in bilateral prefrontal cortical thickness. The changes of FCS in left precuneus were associated with an aging-related decline in global cognition. Taken together, our results suggest changes in FCS with aging with the precuneus as a hub and this may underlie changes in global cognition that accompany aging. These findings help better understand the normal aging mechanism. |
format | Online Article Text |
id | pubmed-7090100 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70901002020-03-31 Longitudinal Changes in Whole-Brain Functional Connectivity Strength Patterns and the Relationship With the Global Cognitive Decline in Older Adults Li, Qiongge Dong, Chao Liu, Tao Chen, Xiaodan Perry, Alistair Jiang, Jiyang Cheng, Jian Niu, Haijun Kochan, Nicole A. Brodaty, Henry Sachdev, Perminder S. Wen, Wei Front Aging Neurosci Neuroscience Aging is associated with changes in brain functional patterns as well as cognition. The present research sought to investigate longitudinal changes in whole brain functional connectivity strength (FCS) and cognitive performance scores in very old cognitively unimpaired individuals. We studied 34 cognitively normal elderly individuals at both baseline and 4-year follow-up (baseline age = 78 ± 3.14 years) with resting-state functional magnetic resonance imaging (r-fMRI), structural MRI scans, and neuropsychological assessments conducted. Voxel-based whole brain FCS was calculated and we found that bilateral superior parietal and medial frontal regions showed decreased FCS, while the supplementary motor area (SMA) and insula showed increased FCS with age, along with a decrease in bilateral prefrontal cortical thickness. The changes of FCS in left precuneus were associated with an aging-related decline in global cognition. Taken together, our results suggest changes in FCS with aging with the precuneus as a hub and this may underlie changes in global cognition that accompany aging. These findings help better understand the normal aging mechanism. Frontiers Media S.A. 2020-03-17 /pmc/articles/PMC7090100/ /pubmed/32256339 http://dx.doi.org/10.3389/fnagi.2020.00071 Text en Copyright © 2020 Li, Dong, Liu, Chen, Perry, Jiang, Cheng, Niu, Kochan, Brodaty, Sachdev and Wen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Li, Qiongge Dong, Chao Liu, Tao Chen, Xiaodan Perry, Alistair Jiang, Jiyang Cheng, Jian Niu, Haijun Kochan, Nicole A. Brodaty, Henry Sachdev, Perminder S. Wen, Wei Longitudinal Changes in Whole-Brain Functional Connectivity Strength Patterns and the Relationship With the Global Cognitive Decline in Older Adults |
title | Longitudinal Changes in Whole-Brain Functional Connectivity Strength Patterns and the Relationship With the Global Cognitive Decline in Older Adults |
title_full | Longitudinal Changes in Whole-Brain Functional Connectivity Strength Patterns and the Relationship With the Global Cognitive Decline in Older Adults |
title_fullStr | Longitudinal Changes in Whole-Brain Functional Connectivity Strength Patterns and the Relationship With the Global Cognitive Decline in Older Adults |
title_full_unstemmed | Longitudinal Changes in Whole-Brain Functional Connectivity Strength Patterns and the Relationship With the Global Cognitive Decline in Older Adults |
title_short | Longitudinal Changes in Whole-Brain Functional Connectivity Strength Patterns and the Relationship With the Global Cognitive Decline in Older Adults |
title_sort | longitudinal changes in whole-brain functional connectivity strength patterns and the relationship with the global cognitive decline in older adults |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090100/ https://www.ncbi.nlm.nih.gov/pubmed/32256339 http://dx.doi.org/10.3389/fnagi.2020.00071 |
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