Clinical Implications of Primary Cilia in Skin Cancer

The primary cilium is a cell surface organelle that is an important component of cellular biology. While it was once believed to be a vestigial structure without biologic function, it is now known to have essential roles in critical cellular signaling pathways such as Hedgehog (HH) and Wnt. The HH a...

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Autores principales: Choudhury, Abrar, Neumann, Neil M., Raleigh, David R., Lang, Ursula E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090118/
https://www.ncbi.nlm.nih.gov/pubmed/31997226
http://dx.doi.org/10.1007/s13555-020-00355-1
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author Choudhury, Abrar
Neumann, Neil M.
Raleigh, David R.
Lang, Ursula E.
author_facet Choudhury, Abrar
Neumann, Neil M.
Raleigh, David R.
Lang, Ursula E.
author_sort Choudhury, Abrar
collection PubMed
description The primary cilium is a cell surface organelle that is an important component of cellular biology. While it was once believed to be a vestigial structure without biologic function, it is now known to have essential roles in critical cellular signaling pathways such as Hedgehog (HH) and Wnt. The HH and Wnt pathways are involved in pathogenesis of basal cell carcinoma and melanoma, respectively, and this knowledge is now beginning to inform therapeutic and diagnostic options for patients. The purpose of this review is to familiarize clinicians with primary cilia biology and how this complex cellular organelle has started to translate into clinical care.
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spelling pubmed-70901182020-03-27 Clinical Implications of Primary Cilia in Skin Cancer Choudhury, Abrar Neumann, Neil M. Raleigh, David R. Lang, Ursula E. Dermatol Ther (Heidelb) Review The primary cilium is a cell surface organelle that is an important component of cellular biology. While it was once believed to be a vestigial structure without biologic function, it is now known to have essential roles in critical cellular signaling pathways such as Hedgehog (HH) and Wnt. The HH and Wnt pathways are involved in pathogenesis of basal cell carcinoma and melanoma, respectively, and this knowledge is now beginning to inform therapeutic and diagnostic options for patients. The purpose of this review is to familiarize clinicians with primary cilia biology and how this complex cellular organelle has started to translate into clinical care. Springer Healthcare 2020-01-29 /pmc/articles/PMC7090118/ /pubmed/31997226 http://dx.doi.org/10.1007/s13555-020-00355-1 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Choudhury, Abrar
Neumann, Neil M.
Raleigh, David R.
Lang, Ursula E.
Clinical Implications of Primary Cilia in Skin Cancer
title Clinical Implications of Primary Cilia in Skin Cancer
title_full Clinical Implications of Primary Cilia in Skin Cancer
title_fullStr Clinical Implications of Primary Cilia in Skin Cancer
title_full_unstemmed Clinical Implications of Primary Cilia in Skin Cancer
title_short Clinical Implications of Primary Cilia in Skin Cancer
title_sort clinical implications of primary cilia in skin cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090118/
https://www.ncbi.nlm.nih.gov/pubmed/31997226
http://dx.doi.org/10.1007/s13555-020-00355-1
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