Cargando…

Rho-Associated Protein Kinase Inhibitor Treatment Promotes Proliferation and Phagocytosis in Trabecular Meshwork Cells

PURPOSE: Continuous reductions in trabecular meshwork (TM) cellularity inhibit aqueous humor (AH) outflow, which is the main cause of primary open-angle glaucoma. Rho-associated protein kinase inhibitor (ROCKi) targets the TM to reduce intraocular pressure (IOP) and increase AH outflow facility. How...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Wenshi, Yang, Xuejiao, Fang, Jingwang, Zhang, Yuqing, Zhu, Wei, Yang, Xian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090161/ https://www.ncbi.nlm.nih.gov/pubmed/32256367 http://dx.doi.org/10.3389/fphar.2020.00302

Ejemplares similares

Rho-associated protein kinase inhibitor induced morphological changes in type VI collagen in the human trabecular meshwork
por: Okamoto, Mizu, et al.
Publicado: (2020)

Rho-Rho kinase pathway in the actomyosin contraction and cell-matrix adhesion in immortalized human trabecular meshwork cells
por: Ramachandran, C., et al.
Publicado: (2011)

Protective Effects of Rapamycin on Trabecular Meshwork Cells in Glucocorticoid-Induced Glaucoma Mice
por: Zhu, Xiaolu, et al.
Publicado: (2020)

Cationic Mechanosensitive Channels Mediate Trabecular Meshwork Responses to Cyclic Mechanical Stretch
por: Chen, Susu, et al.
Publicado: (2022)

Regulatory Roles of Anoctamin-6 in Human Trabecular Meshwork Cells
por: Banerjee, Juni, et al.
Publicado: (2017)

Inhibition of Rho Kinase Induces Antioxidative Molecules and Suppresses Reactive Oxidative Species in Trabecular Meshwork Cells
por: Fujimoto, Tomokazu, et al.
Publicado: (2017)

Expressional and functional involvement of gap junctions in aqueous humor outflow into the ocular trabecular meshwork of the anterior chamber
por: Yu, Hongxia, et al.
Publicado: (2019)

TGFβ2-induced outflow alterations in a bioengineered trabecular meshwork are offset by a rho-associated kinase inhibitor
por: Torrejon, Karen Y., et al.
Publicado: (2016)

Galectin-8 Promotes Cytoskeletal Rearrangement in Trabecular Meshwork Cells through Activation of Rho Signaling
por: Diskin, Shiri, et al.
Publicado: (2012)

Suppression of trabecular meshwork phagocytosis by norepinephrine is associated with nocturnal increase in intraocular pressure in mice
por: Ikegami, Keisuke, et al.
Publicado: (2022)

Integrative transcriptomic and proteomic analysis reveals CD9/ITGA4/PI3K‐Akt axis mediates trabecular meshwork cell apoptosis in human glaucoma
por: Yan, Junwei, et al.
Publicado: (2019)

Human Trabecular Meshwork Progenitors
por: Zhu, Qin, et al.
Publicado: (2019)

Protein expression in human trabecular meshwork: downregulation of RhoGDI by dexamethasone in vitro
por: Yu, Minbin, et al.
Publicado: (2010)

The Dual Effect of Rho-Kinase Inhibition on Trabecular Meshwork Cells Cytoskeleton and Extracellular Matrix in an In Vitro Model of Glaucoma
por: Buffault, Juliette, et al.
Publicado: (2022)

Trabecular Meshwork TREK-1 Channels Function as Polymodal Integrators of Pressure and pH
por: Yarishkin, Oleg, et al.
Publicado: (2019)

YAP and TAZ mediate steroid-induced alterations in the trabecular meshwork cytoskeleton in human trabecular meshwork cells
por: Peng, Jie, et al.
Publicado: (2018)

Apoptosis in the trabecular meshwork of glaucomatous patients
por: Baleriola, Jimena, et al.
Publicado: (2008)

Two-photon imaging of the trabecular meshwork
por: Ammar, David A., et al.
Publicado: (2010)

Surgery on the Trabecular Meshwork: Histopathological Evidence
por: Bhartiya, Shibal, et al.
Publicado: (2015)

Oxidative stress and antioxidants in the trabecular meshwork
por: Wang, Mingxuan, et al.
Publicado: (2019)

Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway
por: Wang, Yiwen, et al.
Publicado: (2019)

Comparative Study of the Effects of Trabecular Meshwork Outflow Drugs on the Permeability and Nitric Oxide Production in Trabecular Meshwork Cells
por: Kim, Jae Woo
Publicado: (2017)

Age-Related Changes in Trabecular Meshwork Imaging
por: Gold, Mark E., et al.
Publicado: (2013)

An In-Depth View of the Porcine Trabecular Meshwork Proteome
por: Funke, Sebastian, et al.
Publicado: (2019)

Sampling trabecular meshwork using TrabEx+
por: Ramjiani, Vipul, et al.
Publicado: (2021)

Primary Human Trabecular Meshwork Model for Pseudoexfoliation
por: Chakraborty, Munmun, et al.
Publicado: (2021)

An Optimized Method to Decellularize Human Trabecular Meshwork
por: Crouch, Devon J., et al.
Publicado: (2022)

Inhibition of TGF-β2–Induced Trabecular Meshwork Fibrosis by Pirfenidone
por: Zhu, Xiaofeng, et al.
Publicado: (2023)

Genomic/proteomic analyses of dexamethasone-treated human trabecular meshwork cells reveal a role for GULP1 and ABR in phagocytosis
por: Faralli, Jennifer A., et al.
Publicado: (2019)

BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork
por: Hernandez, Humberto, et al.
Publicado: (2018)

Link between neurodegeneration and trabecular meshwork injury in glaucomatous patients
por: Zhang, Yong, et al.
Publicado: (2017)

RhoA/ROCK-YAP/TAZ Axis Regulates the Fibrotic Activity in Dexamethasone-Treated Human Trabecular Meshwork Cells
por: Liu, Zhicheng, et al.
Publicado: (2021)

Isolation and Expansion of Multipotent Progenitors from Human Trabecular Meshwork
por: Zhang, Yuan, et al.
Publicado: (2018)

ETX1 is over-expressed in the glaucomatous trabecular meshwork
por: Iragavarapu, Saradha, et al.
Publicado: (2009)

Wnt gene expression in human trabecular meshwork cells
por: Shyam, Rajalekshmy, et al.
Publicado: (2010)

A20 Attenuates the Fibrotic Response in the Trabecular Meshwork
por: Mzyk, Philip, et al.
Publicado: (2022)

Toll-Like Receptor 4 Signaling in the Trabecular Meshwork
por: Mzyk, Philip, et al.
Publicado: (2022)

Segmental outflow dynamics in the trabecular meshwork of living mice
por: Reina-Torres, Ester, et al.
Publicado: (2022)

Accumulation of Asn450Tyr mutant myocilin in ER promotes apoptosis of human trabecular meshwork cells
por: Yan, Xuejing, et al.
Publicado: (2020)

Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma
por: Sun, Hong, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_vfg73ep0bf7rj8sqbsf13fia3r