The Challenge of Hemorrhagic Shock Management During Low-Molecular-Weight Heparin Treatment

The reversal of low-molecular-weight heparin (LMWH) and the management of bleeding patients on LMWH remain highly challenging. Even if LMWH is very extensively administered in the prophylaxis and treatment of venous thrombosis, specific antidotes are lacking, and reversal strategies have very weak g...

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Detalles Bibliográficos
Autores principales: Morotti, Alessandro, Branca, Enrica, Guerrasio, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090193/
https://www.ncbi.nlm.nih.gov/pubmed/32256137
http://dx.doi.org/10.2147/JBM.S232109
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author Morotti, Alessandro
Branca, Enrica
Guerrasio, Angelo
author_facet Morotti, Alessandro
Branca, Enrica
Guerrasio, Angelo
author_sort Morotti, Alessandro
collection PubMed
description The reversal of low-molecular-weight heparin (LMWH) and the management of bleeding patients on LMWH remain highly challenging. Even if LMWH is very extensively administered in the prophylaxis and treatment of venous thrombosis, specific antidotes are lacking, and reversal strategies have very weak grade of evidences on clinical effectiveness. We here describe a reversal strategy with protamine and FVIIa in a patient presenting with hemorrhagic shock and cardiocirculatory arrest.
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spelling pubmed-70901932020-04-01 The Challenge of Hemorrhagic Shock Management During Low-Molecular-Weight Heparin Treatment Morotti, Alessandro Branca, Enrica Guerrasio, Angelo J Blood Med Case Report The reversal of low-molecular-weight heparin (LMWH) and the management of bleeding patients on LMWH remain highly challenging. Even if LMWH is very extensively administered in the prophylaxis and treatment of venous thrombosis, specific antidotes are lacking, and reversal strategies have very weak grade of evidences on clinical effectiveness. We here describe a reversal strategy with protamine and FVIIa in a patient presenting with hemorrhagic shock and cardiocirculatory arrest. Dove 2020-03-19 /pmc/articles/PMC7090193/ /pubmed/32256137 http://dx.doi.org/10.2147/JBM.S232109 Text en © 2020 Morotti et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Morotti, Alessandro
Branca, Enrica
Guerrasio, Angelo
The Challenge of Hemorrhagic Shock Management During Low-Molecular-Weight Heparin Treatment
title The Challenge of Hemorrhagic Shock Management During Low-Molecular-Weight Heparin Treatment
title_full The Challenge of Hemorrhagic Shock Management During Low-Molecular-Weight Heparin Treatment
title_fullStr The Challenge of Hemorrhagic Shock Management During Low-Molecular-Weight Heparin Treatment
title_full_unstemmed The Challenge of Hemorrhagic Shock Management During Low-Molecular-Weight Heparin Treatment
title_short The Challenge of Hemorrhagic Shock Management During Low-Molecular-Weight Heparin Treatment
title_sort challenge of hemorrhagic shock management during low-molecular-weight heparin treatment
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090193/
https://www.ncbi.nlm.nih.gov/pubmed/32256137
http://dx.doi.org/10.2147/JBM.S232109
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