Cargando…

Paeoniflorin Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension by Inhibiting Endothelial-to-Mesenchymal Transition

BACKGROUND: Endothelial cells dysfunction is one of the hallmark pathogenic features of pulmonary arterial hypertension (PAH). Paeoniflorin (PF) is a monoterpene glycoside with endothelial protection, vasodilation, antifibrotic, anti–inflammatory and antioxidative properties. However, the effects of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Min, Peng, Liyao, Liu, Ping, Yang, Mingxia, Zhou, Hong, Ding, Yirui, Wang, Jingjing, Huang, Wen, Tan, Qi, Wang, Yanli, Xie, Weiping, Kong, Hui, Wang, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090222/ https://www.ncbi.nlm.nih.gov/pubmed/32256050 http://dx.doi.org/10.2147/DDDT.S235207

Ejemplares similares

Fasudil Dichloroacetate Alleviates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension by Ameliorating Dysfunction of Pulmonary Arterial Smooth Muscle Cells
por: Liu, Ping, et al.
Publicado: (2021)

The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats
por: Lang, Michaela, et al.
Publicado: (2011)

The Soluble Guanylate Cyclase Stimulator Riociguat Ameliorates Pulmonary Hypertension Induced by Hypoxia and SU5416 in Rats
por: Lang, Michaela, et al.
Publicado: (2012)

Response to: Are endothelial cell proliferation and mesenchymal transition as distinguishing characteristics of 3-week Sugen5416/hypoxia mice model?
por: Rodor, Julie, et al.
Publicado: (2023)

Human Mesenchymal Stem Cell Therapy Reverses Su5416/Hypoxia-Induced Pulmonary Arterial Hypertension in Mice
por: Alencar, Allan K. N., et al.
Publicado: (2018)

SU5416 does not attenuate early RV angiogenesis in the murine chronic hypoxia PH model
por: Peloquin, Grace L., et al.
Publicado: (2019)

Paeoniflorin prevents hypoxia-induced epithelial–mesenchymal transition in human breast cancer cells
por: Zhou, Zhenyu, et al.
Publicado: (2016)

Gut microbiota modification suppresses the development of pulmonary arterial hypertension in an SU5416/hypoxia rat model
por: Sanada, Takayuki J., et al.
Publicado: (2020)

SU5416 attenuated lipopolysaccharide-induced acute lung injury in mice by modulating properties of vascular endothelial cells
por: Huang, Xuqing, et al.
Publicado: (2019)

Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing TAK1-MAPK/NF-κB pathways
por: Yu, Min, et al.
Publicado: (2022)

The Isoquinoline-Sulfonamide Compound H-1337 Attenuates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension in Rats
por: Shoji, Hiroki, et al.
Publicado: (2021)

Effects of SU5416 and a vascular endothelial growth factor neutralizing antibody on wear debris-induced inflammatory osteolysis in a mouse model
por: Ren, Weiping, et al.
Publicado: (2011)

Natural reversal of pulmonary vascular remodeling and right ventricular remodeling in SU5416/hypoxia-treated Sprague-Dawley rats
por: Zungu-Edmondson, Makhosazane, et al.
Publicado: (2017)

Partially hydrolyzed guar gum suppresses the progression of pulmonary arterial hypertension in a SU5416/hypoxia rat model
por: Sanada, Takayuki J., et al.
Publicado: (2023)

SU5416 induces premature senescence in endothelial progenitor cells from patients with age-related macular degeneration
por: Thill, Michelle, et al.
Publicado: (2011)

Echocardiographic evaluation of right heart failure which might be associated with DNA damage response in SU5416-hypoxia induced pulmonary hypertension rat model
por: Kuang, Meidan, et al.
Publicado: (2023)

The selective PGI(2) receptor agonist selexipag ameliorates Sugen 5416/hypoxia-induced pulmonary arterial hypertension in rats
por: Honda, Yohei, et al.
Publicado: (2020)

Paeoniflorin alleviates the progression of retinal vein occlusion via inhibiting hypoxia inducible factor-1α/vascular endothelial growth factor/STAT3 pathway
por: Kong, Lingchun, et al.
Publicado: (2022)

SU5416 plus hypoxia but not selective VEGFR2 inhibition with cabozantinib plus hypoxia induces pulmonary hypertension in rats: potential role of BMPR2 signaling
por: Sitapara, Ravikumar, et al.
Publicado: (2021)

Effects of the vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor SU5416 on in vitro cultures of Plasmodium falciparum
por: Hempel, Casper, et al.
Publicado: (2014)

Upregulation of Aquaporin 1 Mediates Increased Migration and Proliferation in Pulmonary Vascular Cells From the Rat SU5416/Hypoxia Model of Pulmonary Hypertension
por: Yun, Xin, et al.
Publicado: (2021)

Vascular Endothelial Growth Factor Receptor Inhibitor SU5416 Suppresses Lymphocyte Generation and Immune Responses in Mice by Increasing Plasma Corticosterone
por: Grailer, Jamison J., et al.
Publicado: (2013)

SU5416, a VEGF Receptor Inhibitor and Ligand of the AHR, Represents a New Alternative for Immunomodulation
por: Mezrich, Joshua D., et al.
Publicado: (2012)

Anti-Tumor Effects of Paeoniflorin on Epithelial-To-Mesenchymal Transition in Human Colorectal Cancer Cells
por: Zhang, Jia-Wei, et al.
Publicado: (2018)

Paeoniflorin Ameliorates Hyperprolactinemia-Induced Inhibition of Osteoblastogenesis by Suppressing the NF-κB Signaling Pathway
por: Sun, Xiaohong, et al.
Publicado: (2022)

Normalization of the Lymph Node T Cell Stromal Microenvironment in lpr/lpr Mice Is Associated with SU5416-Induced Reduction in Autoantibodies
por: Chyou, Susan, et al.
Publicado: (2012)

Paeoniflorin ameliorates acute necrotizing pancreatitis and pancreatitis-induced acute renal injury
por: Wang, Peng, et al.
Publicado: (2016)

Inhibition of Bruton's Tyrosine Kinase Alleviates Monocrotaline-Induced Pulmonary Arterial Hypertension by Modulating Macrophage Polarization
por: Yu, Min, et al.
Publicado: (2022)

Paeoniflorin ameliorates glycemic variability-induced oxidative stress and platelet activation in HUVECs and DM rats
por: Huang, Ye, et al.
Publicado: (2020)

Paeoniflorin ameliorates interferon-alpha-induced neuroinflammation and depressive-like behaviors in mice
por: Li, Jianwei, et al.
Publicado: (2016)

RUNX3 modulates hypoxia-induced endothelial-to-mesenchymal transition of human cardiac microvascular endothelial cells
por: Liu, Yanhua, et al.
Publicado: (2017)

Human Umbilical Cord-Derived Mesenchymal Stem Cells Repair SU5416-Injured Emphysema by Inhibiting Apoptosis via Rescuing VEGF-VEGFR2-AKT Pathway in Rats
por: Chen, Qin, et al.
Publicado: (2022)

Hypoxia induces endothelial-mesenchymal transition in pulmonary vascular remodeling
por: Zhang, Bo, et al.
Publicado: (2018)

Paeoniflorin ameliorates ulcerative colitis by modulating the dendritic cell-mediated T(H)17/T(reg) balance
por: Zheng, Kai, et al.
Publicado: (2020)

Paeoniflorin ameliorates cognitive impairment in Parkinson’s disease via JNK/p53 signaling
por: He, Zhu-qing, et al.
Publicado: (2022)

Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain
por: Zhou, Danli, et al.
Publicado: (2019)

The Regulatory Effects of Paeoniflorin and Its Derivative Paeoniflorin-6′-O-Benzene Sulfonate CP-25 on Inflammation and Immune Diseases
por: Tu, Jiajie, et al.
Publicado: (2019)

Paeoniflorin in Paeoniaceae: Distribution, influencing factors, and biosynthesis
por: Zhang, Xiao-Xiao, et al.
Publicado: (2022)

Hypoxia Upregulates NOTCH3 Signaling Pathway to Promote Endothelial-Mesenchymal Transition in Pulmonary Artery Endothelial Cells
por: Wang, Li-Le, et al.
Publicado: (2021)

A Phase I study of the angiogenesis inhibitor SU5416 (semaxanib) in solid tumours, incorporating dynamic contrast MR pharmacodynamic end points
por: O'Donnell, A, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_4gr1ssahima414jq1ocrbovd8v