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Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers

Recent observations revealed a novel role of angiotensin-converting enzyme 2 and the angiotensin II type-1 receptor (AT1R) in lung injury, thereby extending knowledge about the functions of the angiotensin system. Angiotensin II, whose target is the AT1R, is a potent vasoconstrictor. Accordingly, an...

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Autores principales: Szolnoki, Zoltán, Havasi, Viktória, Talián, Gábor, Bene, Judit, Komlósi, Katalin, Somogyvári, Ferenc, Kondacs, András, Szabó, Mihály, Fodor, Lajos, Bodor, Anita, Melegh, Béla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Humana Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090441/
https://www.ncbi.nlm.nih.gov/pubmed/16691016
http://dx.doi.org/10.1385/JMN:28:3:285
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author Szolnoki, Zoltán
Havasi, Viktória
Talián, Gábor
Bene, Judit
Komlósi, Katalin
Somogyvári, Ferenc
Kondacs, András
Szabó, Mihály
Fodor, Lajos
Bodor, Anita
Melegh, Béla
author_facet Szolnoki, Zoltán
Havasi, Viktória
Talián, Gábor
Bene, Judit
Komlósi, Katalin
Somogyvári, Ferenc
Kondacs, András
Szabó, Mihály
Fodor, Lajos
Bodor, Anita
Melegh, Béla
author_sort Szolnoki, Zoltán
collection PubMed
description Recent observations revealed a novel role of angiotensin-converting enzyme 2 and the angiotensin II type-1 receptor (AT1R) in lung injury, thereby extending knowledge about the functions of the angiotensin system. Angiotensin II, whose target is the AT1R, is a potent vasoconstrictor. Accordingly, an imbalance leading to enhanced activity of the angiotensin II-AT1R axis is postulated to contribute to both circulatory disturbances and lung injury. In this context, a functional single-nucleotide polymorphism, AT1R A1166C, which leads to enhanced responsiveness of the AT1R, has been postulated as a candidate susceptibility factor for ischemic stroke. The aim of our study was to investigate its occurrence in ischemic stroke and to analyze its possible synergistic associations with clinical risk factors. Genetic and clinical data on 308 consecutive patients with acutely developing ischemic stroke were analyzed. A total of 272 stroke and neuroimaging alteration-free subjects served as a control group. Univariate and logistic regression statistical approaches were used. Alone, the AT1R 1166C allele did not pose a risk of stroke. In hypertensive smokers, however, it was associated with an increased risk of ischemic stroke (OR 22.3, 95% CI 5.8–110.2, p<0.001). Further subgroup analysis revealed the same association for both small-vessel (OR 24.3, 95% CI 6.1–121.1, p<0.001) and large-vessel (OR 21.3, 95% CI 4.6–81.1, p<0.001) infarction. On a pathophysiological basis, our results suggest the possibility that the AT1R A1166C polymorphism might give rise to ischemic stroke indirectly via an unfavorable effect on the cardiorespiratory function.
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spelling pubmed-70904412020-03-24 Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers Szolnoki, Zoltán Havasi, Viktória Talián, Gábor Bene, Judit Komlósi, Katalin Somogyvári, Ferenc Kondacs, András Szabó, Mihály Fodor, Lajos Bodor, Anita Melegh, Béla J Mol Neurosci Original Article Recent observations revealed a novel role of angiotensin-converting enzyme 2 and the angiotensin II type-1 receptor (AT1R) in lung injury, thereby extending knowledge about the functions of the angiotensin system. Angiotensin II, whose target is the AT1R, is a potent vasoconstrictor. Accordingly, an imbalance leading to enhanced activity of the angiotensin II-AT1R axis is postulated to contribute to both circulatory disturbances and lung injury. In this context, a functional single-nucleotide polymorphism, AT1R A1166C, which leads to enhanced responsiveness of the AT1R, has been postulated as a candidate susceptibility factor for ischemic stroke. The aim of our study was to investigate its occurrence in ischemic stroke and to analyze its possible synergistic associations with clinical risk factors. Genetic and clinical data on 308 consecutive patients with acutely developing ischemic stroke were analyzed. A total of 272 stroke and neuroimaging alteration-free subjects served as a control group. Univariate and logistic regression statistical approaches were used. Alone, the AT1R 1166C allele did not pose a risk of stroke. In hypertensive smokers, however, it was associated with an increased risk of ischemic stroke (OR 22.3, 95% CI 5.8–110.2, p<0.001). Further subgroup analysis revealed the same association for both small-vessel (OR 24.3, 95% CI 6.1–121.1, p<0.001) and large-vessel (OR 21.3, 95% CI 4.6–81.1, p<0.001) infarction. On a pathophysiological basis, our results suggest the possibility that the AT1R A1166C polymorphism might give rise to ischemic stroke indirectly via an unfavorable effect on the cardiorespiratory function. Humana Press 2006 /pmc/articles/PMC7090441/ /pubmed/16691016 http://dx.doi.org/10.1385/JMN:28:3:285 Text en © Humana Press Inc 2006 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Szolnoki, Zoltán
Havasi, Viktória
Talián, Gábor
Bene, Judit
Komlósi, Katalin
Somogyvári, Ferenc
Kondacs, András
Szabó, Mihály
Fodor, Lajos
Bodor, Anita
Melegh, Béla
Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers
title Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers
title_full Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers
title_fullStr Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers
title_full_unstemmed Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers
title_short Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers
title_sort angiotensin ii type-1 receptor a1166c polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090441/
https://www.ncbi.nlm.nih.gov/pubmed/16691016
http://dx.doi.org/10.1385/JMN:28:3:285
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