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Review: Micronutrient Selenium Deficiency Influences Evolution of Some Viral Infectious Diseases
Recently emerged viral infectious diseases (VIDs) include HIV/AIDS, influenzas H5N1 and 2009 H1N1, SARS, and Ebola hemorrhagic fevers. Earlier research determined metabolic oxidative stress in hosts deficient in antioxidant selenium (Se) (<1 μMol Se/L of blood) induces both impaired human host im...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Humana Press Inc
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090490/ https://www.ncbi.nlm.nih.gov/pubmed/21318622 http://dx.doi.org/10.1007/s12011-011-8977-1 |
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author | Harthill, Michalann |
author_facet | Harthill, Michalann |
author_sort | Harthill, Michalann |
collection | PubMed |
description | Recently emerged viral infectious diseases (VIDs) include HIV/AIDS, influenzas H5N1 and 2009 H1N1, SARS, and Ebola hemorrhagic fevers. Earlier research determined metabolic oxidative stress in hosts deficient in antioxidant selenium (Se) (<1 μMol Se/L of blood) induces both impaired human host immunocompetence and rapidly mutated benign variants of RNA viruses to virulence. These viral mutations are consistent, rather than stochastic, and long-lived. When Se-deficient virus-infected hosts were supplemented with dietary Se, viral mutation rates diminished and immunocompetence improved. Herein is described the role of micronutrient Se deficiency on the evolution of some contemporary RNA viruses and their subsequent VIDs. Distinguishing cellular and biomolecular evidence for several VIDs suggests that environmental conditions conducive to chronic dietary Se deprivation could be monitored for bioindicators of incipient viral virulence and subsequent pathogenesis. |
format | Online Article Text |
id | pubmed-7090490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Humana Press Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-70904902020-03-24 Review: Micronutrient Selenium Deficiency Influences Evolution of Some Viral Infectious Diseases Harthill, Michalann Biol Trace Elem Res Article Recently emerged viral infectious diseases (VIDs) include HIV/AIDS, influenzas H5N1 and 2009 H1N1, SARS, and Ebola hemorrhagic fevers. Earlier research determined metabolic oxidative stress in hosts deficient in antioxidant selenium (Se) (<1 μMol Se/L of blood) induces both impaired human host immunocompetence and rapidly mutated benign variants of RNA viruses to virulence. These viral mutations are consistent, rather than stochastic, and long-lived. When Se-deficient virus-infected hosts were supplemented with dietary Se, viral mutation rates diminished and immunocompetence improved. Herein is described the role of micronutrient Se deficiency on the evolution of some contemporary RNA viruses and their subsequent VIDs. Distinguishing cellular and biomolecular evidence for several VIDs suggests that environmental conditions conducive to chronic dietary Se deprivation could be monitored for bioindicators of incipient viral virulence and subsequent pathogenesis. Humana Press Inc 2011-02-12 2011 /pmc/articles/PMC7090490/ /pubmed/21318622 http://dx.doi.org/10.1007/s12011-011-8977-1 Text en © Springer Science+Business Media, LLC 2011 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Harthill, Michalann Review: Micronutrient Selenium Deficiency Influences Evolution of Some Viral Infectious Diseases |
title | Review: Micronutrient Selenium Deficiency Influences Evolution of Some Viral Infectious Diseases |
title_full | Review: Micronutrient Selenium Deficiency Influences Evolution of Some Viral Infectious Diseases |
title_fullStr | Review: Micronutrient Selenium Deficiency Influences Evolution of Some Viral Infectious Diseases |
title_full_unstemmed | Review: Micronutrient Selenium Deficiency Influences Evolution of Some Viral Infectious Diseases |
title_short | Review: Micronutrient Selenium Deficiency Influences Evolution of Some Viral Infectious Diseases |
title_sort | review: micronutrient selenium deficiency influences evolution of some viral infectious diseases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090490/ https://www.ncbi.nlm.nih.gov/pubmed/21318622 http://dx.doi.org/10.1007/s12011-011-8977-1 |
work_keys_str_mv | AT harthillmichalann reviewmicronutrientseleniumdeficiencyinfluencesevolutionofsomeviralinfectiousdiseases |