What the granins tell us about the formation of secretory granules in neuroendocrine cells

The biochemical properties of the granins, studied in vitro and in a perforated TGN system, support the concept that the Sciective aggregation of regulated secretory proteins, promoted by the specific lumenal milieu of the TGN, is a key step in their segregation from constitutive secretory proteins...

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Detalles Bibliográficos
Autores principales: Chanat, Eric, Pimplikar, Sanjay W., Stinchcombe, Jane C., Huttner, Wieland B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Humana Press 1991
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090494/
https://www.ncbi.nlm.nih.gov/pubmed/1726891
http://dx.doi.org/10.1007/BF02989882
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author Chanat, Eric
Pimplikar, Sanjay W.
Stinchcombe, Jane C.
Huttner, Wieland B.
author_facet Chanat, Eric
Pimplikar, Sanjay W.
Stinchcombe, Jane C.
Huttner, Wieland B.
author_sort Chanat, Eric
collection PubMed
description The biochemical properties of the granins, studied in vitro and in a perforated TGN system, support the concept that the Sciective aggregation of regulated secretory proteins, promoted by the specific lumenal milieu of the TGN, is a key step in their segregation from constitutive secretory proteins in this compartment. A recently identified membrane-associated form of the granins is likely to also be involved in this aggregation, as well as in the membrane envelopment of the aggregate during the formation of an immature secretory granule.
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spelling pubmed-70904942020-03-24 What the granins tell us about the formation of secretory granules in neuroendocrine cells Chanat, Eric Pimplikar, Sanjay W. Stinchcombe, Jane C. Huttner, Wieland B. Cell Biophys Article The biochemical properties of the granins, studied in vitro and in a perforated TGN system, support the concept that the Sciective aggregation of regulated secretory proteins, promoted by the specific lumenal milieu of the TGN, is a key step in their segregation from constitutive secretory proteins in this compartment. A recently identified membrane-associated form of the granins is likely to also be involved in this aggregation, as well as in the membrane envelopment of the aggregate during the formation of an immature secretory granule. Humana Press 1991 /pmc/articles/PMC7090494/ /pubmed/1726891 http://dx.doi.org/10.1007/BF02989882 Text en © The Humana Press, Inc 1992 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Chanat, Eric
Pimplikar, Sanjay W.
Stinchcombe, Jane C.
Huttner, Wieland B.
What the granins tell us about the formation of secretory granules in neuroendocrine cells
title What the granins tell us about the formation of secretory granules in neuroendocrine cells
title_full What the granins tell us about the formation of secretory granules in neuroendocrine cells
title_fullStr What the granins tell us about the formation of secretory granules in neuroendocrine cells
title_full_unstemmed What the granins tell us about the formation of secretory granules in neuroendocrine cells
title_short What the granins tell us about the formation of secretory granules in neuroendocrine cells
title_sort what the granins tell us about the formation of secretory granules in neuroendocrine cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090494/
https://www.ncbi.nlm.nih.gov/pubmed/1726891
http://dx.doi.org/10.1007/BF02989882
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