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Is there a subtype of developmental Parkinson's disease?

Evidence accumulates suggesting that environmental factors including viral and risk factors associated with pregnancy and birth-giving, may increase the incidence of hypokinesia/parkinsonism in early life, or PD in later life. Such environmental pre-, peri- or postnatal stress may lead to disturbanc...

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Detalles Bibliográficos
Autor principal: Riederer, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090941/
https://www.ncbi.nlm.nih.gov/pubmed/12832222
http://dx.doi.org/10.1007/BF03033370
Descripción
Sumario:Evidence accumulates suggesting that environmental factors including viral and risk factors associated with pregnancy and birth-giving, may increase the incidence of hypokinesia/parkinsonism in early life, or PD in later life. Such environmental pre-, peri- or postnatal stress may lead to disturbances in the developing brain and malformations in regions of particular interest and associated with PD. Genetic predisposition to hypoactivity plus environmental effects may lead to reorganization of brain circuitry including changes in monoaminergic and/or EAA systems, leading to a subtype of PD, i.e. genetic, drug induced, viral, developmental and other possible subtypes. The spectrum disorder of PD is going to be further substantiated into various etiopathologically verifyable subgroups.