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Is there a subtype of developmental Parkinson's disease?
Evidence accumulates suggesting that environmental factors including viral and risk factors associated with pregnancy and birth-giving, may increase the incidence of hypokinesia/parkinsonism in early life, or PD in later life. Such environmental pre-, peri- or postnatal stress may lead to disturbanc...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer-Verlag
2003
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090941/ https://www.ncbi.nlm.nih.gov/pubmed/12832222 http://dx.doi.org/10.1007/BF03033370 |
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author | Riederer, P. |
author_facet | Riederer, P. |
author_sort | Riederer, P. |
collection | PubMed |
description | Evidence accumulates suggesting that environmental factors including viral and risk factors associated with pregnancy and birth-giving, may increase the incidence of hypokinesia/parkinsonism in early life, or PD in later life. Such environmental pre-, peri- or postnatal stress may lead to disturbances in the developing brain and malformations in regions of particular interest and associated with PD. Genetic predisposition to hypoactivity plus environmental effects may lead to reorganization of brain circuitry including changes in monoaminergic and/or EAA systems, leading to a subtype of PD, i.e. genetic, drug induced, viral, developmental and other possible subtypes. The spectrum disorder of PD is going to be further substantiated into various etiopathologically verifyable subgroups. |
format | Online Article Text |
id | pubmed-7090941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-70909412020-03-24 Is there a subtype of developmental Parkinson's disease? Riederer, P. Neurotox Res Article Evidence accumulates suggesting that environmental factors including viral and risk factors associated with pregnancy and birth-giving, may increase the incidence of hypokinesia/parkinsonism in early life, or PD in later life. Such environmental pre-, peri- or postnatal stress may lead to disturbances in the developing brain and malformations in regions of particular interest and associated with PD. Genetic predisposition to hypoactivity plus environmental effects may lead to reorganization of brain circuitry including changes in monoaminergic and/or EAA systems, leading to a subtype of PD, i.e. genetic, drug induced, viral, developmental and other possible subtypes. The spectrum disorder of PD is going to be further substantiated into various etiopathologically verifyable subgroups. Springer-Verlag 2003 /pmc/articles/PMC7090941/ /pubmed/12832222 http://dx.doi.org/10.1007/BF03033370 Text en © Springer 2003 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Riederer, P. Is there a subtype of developmental Parkinson's disease? |
title | Is there a subtype of developmental Parkinson's disease? |
title_full | Is there a subtype of developmental Parkinson's disease? |
title_fullStr | Is there a subtype of developmental Parkinson's disease? |
title_full_unstemmed | Is there a subtype of developmental Parkinson's disease? |
title_short | Is there a subtype of developmental Parkinson's disease? |
title_sort | is there a subtype of developmental parkinson's disease? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090941/ https://www.ncbi.nlm.nih.gov/pubmed/12832222 http://dx.doi.org/10.1007/BF03033370 |
work_keys_str_mv | AT riedererp isthereasubtypeofdevelopmentalparkinsonsdisease |