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Human bocavirus in children hospitalized for acute respiratory tract infection in Rome

BACKGROUND: The role of human bocavirus (HBoV) as a respiratory pathogen has not been fulfilled yet. We aimed to describe clinical and serological characteristics of children with HBoV hospitalized for acute respiratory tract infection and to evaluate whether differences occur between HBoV alone and...

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Autores principales: Petrarca, Laura, Nenna, Raffaella, Frassanito, Antonella, Pierangeli, Alessandra, Di Mattia, Greta, Scagnolari, Carolina, Midulla, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091143/
https://www.ncbi.nlm.nih.gov/pubmed/31776891
http://dx.doi.org/10.1007/s12519-019-00324-5
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author Petrarca, Laura
Nenna, Raffaella
Frassanito, Antonella
Pierangeli, Alessandra
Di Mattia, Greta
Scagnolari, Carolina
Midulla, Fabio
author_facet Petrarca, Laura
Nenna, Raffaella
Frassanito, Antonella
Pierangeli, Alessandra
Di Mattia, Greta
Scagnolari, Carolina
Midulla, Fabio
author_sort Petrarca, Laura
collection PubMed
description BACKGROUND: The role of human bocavirus (HBoV) as a respiratory pathogen has not been fulfilled yet. We aimed to describe clinical and serological characteristics of children with HBoV hospitalized for acute respiratory tract infection and to evaluate whether differences occur between HBoV alone and in co-infection. METHODS: We retrospectively reviewed data from 60 children (median age of 6.2 months, range 0.6–70.9) hospitalized for acute respiratory symptoms, with HBoV detected from a respiratory sample, using a reverse transcriptase-PCR for 14 respiratory viruses (including respiratory syncytial virus (RSV), influenza virus A and B, human coronavirus OC43, 229E, NL-63 and HUK1, adenovirus, rhinovirus, parainfluenza virus1–3, and human metapneumovirus). RESULTS: HBoV was detected alone in 29 (48.3%) patients, while in co-infection with other viruses in 31 patients (51.7%), with a peak between December and January. Among the 60 patients, 34 were bronchiolitis, 19 wheezing, 3 pneumonia, 2 upper respiratory tract infection, and 2 whooping cough. Seven children (11.6%) required admission to the paediatric intensive care unit (PICU) for respiratory failure. No differences was observed in age, family history for atopy and/or asthma, clinical presentations, chest X-ray, or laboratory findings in children with HBoV alone vs. multiple viral detection. RSV was the most frequently co-detected virus (61.3%). When compared with HBoV detection alone, the co-detection of RSV and HBoV was associated with male sex (P = 0.013), younger age (P = 0.01), and lower blood neutrophil count (P = 0.032). CONCLUSIONS: HBoV can be detected alone and in co-infection respiratory samples of children with an acute respiratory tract infection. A cause–effect relationship between HBoV and respiratory infection is not clear, so further studies are needed to clarify this point.
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spelling pubmed-70911432020-03-24 Human bocavirus in children hospitalized for acute respiratory tract infection in Rome Petrarca, Laura Nenna, Raffaella Frassanito, Antonella Pierangeli, Alessandra Di Mattia, Greta Scagnolari, Carolina Midulla, Fabio World J Pediatr Original Article BACKGROUND: The role of human bocavirus (HBoV) as a respiratory pathogen has not been fulfilled yet. We aimed to describe clinical and serological characteristics of children with HBoV hospitalized for acute respiratory tract infection and to evaluate whether differences occur between HBoV alone and in co-infection. METHODS: We retrospectively reviewed data from 60 children (median age of 6.2 months, range 0.6–70.9) hospitalized for acute respiratory symptoms, with HBoV detected from a respiratory sample, using a reverse transcriptase-PCR for 14 respiratory viruses (including respiratory syncytial virus (RSV), influenza virus A and B, human coronavirus OC43, 229E, NL-63 and HUK1, adenovirus, rhinovirus, parainfluenza virus1–3, and human metapneumovirus). RESULTS: HBoV was detected alone in 29 (48.3%) patients, while in co-infection with other viruses in 31 patients (51.7%), with a peak between December and January. Among the 60 patients, 34 were bronchiolitis, 19 wheezing, 3 pneumonia, 2 upper respiratory tract infection, and 2 whooping cough. Seven children (11.6%) required admission to the paediatric intensive care unit (PICU) for respiratory failure. No differences was observed in age, family history for atopy and/or asthma, clinical presentations, chest X-ray, or laboratory findings in children with HBoV alone vs. multiple viral detection. RSV was the most frequently co-detected virus (61.3%). When compared with HBoV detection alone, the co-detection of RSV and HBoV was associated with male sex (P = 0.013), younger age (P = 0.01), and lower blood neutrophil count (P = 0.032). CONCLUSIONS: HBoV can be detected alone and in co-infection respiratory samples of children with an acute respiratory tract infection. A cause–effect relationship between HBoV and respiratory infection is not clear, so further studies are needed to clarify this point. Springer Singapore 2019-11-27 2020 /pmc/articles/PMC7091143/ /pubmed/31776891 http://dx.doi.org/10.1007/s12519-019-00324-5 Text en © Children's Hospital, Zhejiang University School of Medicine 2019 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Petrarca, Laura
Nenna, Raffaella
Frassanito, Antonella
Pierangeli, Alessandra
Di Mattia, Greta
Scagnolari, Carolina
Midulla, Fabio
Human bocavirus in children hospitalized for acute respiratory tract infection in Rome
title Human bocavirus in children hospitalized for acute respiratory tract infection in Rome
title_full Human bocavirus in children hospitalized for acute respiratory tract infection in Rome
title_fullStr Human bocavirus in children hospitalized for acute respiratory tract infection in Rome
title_full_unstemmed Human bocavirus in children hospitalized for acute respiratory tract infection in Rome
title_short Human bocavirus in children hospitalized for acute respiratory tract infection in Rome
title_sort human bocavirus in children hospitalized for acute respiratory tract infection in rome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091143/
https://www.ncbi.nlm.nih.gov/pubmed/31776891
http://dx.doi.org/10.1007/s12519-019-00324-5
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