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Illuminating the Gateway of Gene Silencing: Perspective of RNA Interference Technology in Clinical Therapeutics

A novel laboratory revolution for disease therapy, the RNA interference (RNAi) technology, has adopted a new era of molecular research as the next generation “Gene-targeted prophylaxis.” In this review, we have focused on the chief technological challenges associated with the efforts to develop RNAi...

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Detalles Bibliográficos
Autores principales: Sindhu, Annu, Arora, Pooja, Chaudhury, Ashok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Humana Press Inc 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091241/
https://www.ncbi.nlm.nih.gov/pubmed/21947958
http://dx.doi.org/10.1007/s12033-011-9456-9
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author Sindhu, Annu
Arora, Pooja
Chaudhury, Ashok
author_facet Sindhu, Annu
Arora, Pooja
Chaudhury, Ashok
author_sort Sindhu, Annu
collection PubMed
description A novel laboratory revolution for disease therapy, the RNA interference (RNAi) technology, has adopted a new era of molecular research as the next generation “Gene-targeted prophylaxis.” In this review, we have focused on the chief technological challenges associated with the efforts to develop RNAi-based therapeutics that may guide the biomedical researchers. Many non-curable maladies, like neurodegenerative diseases and cancers have effectively been cured using this technology. Rapid advances are still in progress for the development of RNAi-based technologies that will be having a major impact on medical research. We have highlighted the recent discoveries associated with the phenomenon of RNAi, expression of silencing molecules in mammals along with the vector systems used for disease therapeutics.
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spelling pubmed-70912412020-03-24 Illuminating the Gateway of Gene Silencing: Perspective of RNA Interference Technology in Clinical Therapeutics Sindhu, Annu Arora, Pooja Chaudhury, Ashok Mol Biotechnol Review A novel laboratory revolution for disease therapy, the RNA interference (RNAi) technology, has adopted a new era of molecular research as the next generation “Gene-targeted prophylaxis.” In this review, we have focused on the chief technological challenges associated with the efforts to develop RNAi-based therapeutics that may guide the biomedical researchers. Many non-curable maladies, like neurodegenerative diseases and cancers have effectively been cured using this technology. Rapid advances are still in progress for the development of RNAi-based technologies that will be having a major impact on medical research. We have highlighted the recent discoveries associated with the phenomenon of RNAi, expression of silencing molecules in mammals along with the vector systems used for disease therapeutics. Humana Press Inc 2011-09-25 2012 /pmc/articles/PMC7091241/ /pubmed/21947958 http://dx.doi.org/10.1007/s12033-011-9456-9 Text en © Springer Science+Business Media, LLC 2011 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Sindhu, Annu
Arora, Pooja
Chaudhury, Ashok
Illuminating the Gateway of Gene Silencing: Perspective of RNA Interference Technology in Clinical Therapeutics
title Illuminating the Gateway of Gene Silencing: Perspective of RNA Interference Technology in Clinical Therapeutics
title_full Illuminating the Gateway of Gene Silencing: Perspective of RNA Interference Technology in Clinical Therapeutics
title_fullStr Illuminating the Gateway of Gene Silencing: Perspective of RNA Interference Technology in Clinical Therapeutics
title_full_unstemmed Illuminating the Gateway of Gene Silencing: Perspective of RNA Interference Technology in Clinical Therapeutics
title_short Illuminating the Gateway of Gene Silencing: Perspective of RNA Interference Technology in Clinical Therapeutics
title_sort illuminating the gateway of gene silencing: perspective of rna interference technology in clinical therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091241/
https://www.ncbi.nlm.nih.gov/pubmed/21947958
http://dx.doi.org/10.1007/s12033-011-9456-9
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