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Genetic variation analyses of nsp2 gene of PRRSV in Ningxia Hui Autonomous Region of China

To gain a better understanding of the genetic diversity and evolution of PRRSV in the Ningxia Hui Nationality Autonomous Region (Ningxia) of China, the nsp2 genes from a series of PRRSV strains collected from the region in 2007 were partially sequenced. These sequences were then analyzed along with...

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Autores principales: Tian, Hong, Wu, Jing-yan, Yin, Shuang-hui, Shang, You-jun, Man, Zi-ping, Zhao, Na, Jin, Ye, Liu, Xiang-tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Wuhan Institute of Virology, CAS 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091468/
http://dx.doi.org/10.1007/s12250-009-3017-4
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author Tian, Hong
Wu, Jing-yan
Yin, Shuang-hui
Shang, You-jun
Man, Zi-ping
Zhao, Na
Jin, Ye
Liu, Xiang-tao
author_facet Tian, Hong
Wu, Jing-yan
Yin, Shuang-hui
Shang, You-jun
Man, Zi-ping
Zhao, Na
Jin, Ye
Liu, Xiang-tao
author_sort Tian, Hong
collection PubMed
description To gain a better understanding of the genetic diversity and evolution of PRRSV in the Ningxia Hui Nationality Autonomous Region (Ningxia) of China, the nsp2 genes from a series of PRRSV strains collected from the region in 2007 were partially sequenced. These sequences were then analyzed along with the classical strain (ch-1a) and two other epidemic strains SD (3) and SD2006. Comparison of the nucleotide sequence with ch-1a indicated that nsp2 genes of seventeen Ningxia isolates (NX strain) have deletions of 87 nucleotides. Sequence analysis indicated that homology between the Ningxia strain and ch-1a was 60.3%–79.9% in the nucleotide sequence, and homology between the NX strains and SD strains was 80.3%–98.8% in the nucleotide sequence. The nsp2 genes of the seventeen isolates had 74.9%–100% nucleotide sequence identities with each other. This study was undertaken to assess the regional variation of prevalent PRRSV and to establish a sequence database for PRRSV molecular epidemiological studies.
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spelling pubmed-70914682020-03-24 Genetic variation analyses of nsp2 gene of PRRSV in Ningxia Hui Autonomous Region of China Tian, Hong Wu, Jing-yan Yin, Shuang-hui Shang, You-jun Man, Zi-ping Zhao, Na Jin, Ye Liu, Xiang-tao Virol Sin Article To gain a better understanding of the genetic diversity and evolution of PRRSV in the Ningxia Hui Nationality Autonomous Region (Ningxia) of China, the nsp2 genes from a series of PRRSV strains collected from the region in 2007 were partially sequenced. These sequences were then analyzed along with the classical strain (ch-1a) and two other epidemic strains SD (3) and SD2006. Comparison of the nucleotide sequence with ch-1a indicated that nsp2 genes of seventeen Ningxia isolates (NX strain) have deletions of 87 nucleotides. Sequence analysis indicated that homology between the Ningxia strain and ch-1a was 60.3%–79.9% in the nucleotide sequence, and homology between the NX strains and SD strains was 80.3%–98.8% in the nucleotide sequence. The nsp2 genes of the seventeen isolates had 74.9%–100% nucleotide sequence identities with each other. This study was undertaken to assess the regional variation of prevalent PRRSV and to establish a sequence database for PRRSV molecular epidemiological studies. SP Wuhan Institute of Virology, CAS 2009-05-28 /pmc/articles/PMC7091468/ http://dx.doi.org/10.1007/s12250-009-3017-4 Text en © Wuhan Institute of Virology, CAS and Springer-Verlag GmbH 2009 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Tian, Hong
Wu, Jing-yan
Yin, Shuang-hui
Shang, You-jun
Man, Zi-ping
Zhao, Na
Jin, Ye
Liu, Xiang-tao
Genetic variation analyses of nsp2 gene of PRRSV in Ningxia Hui Autonomous Region of China
title Genetic variation analyses of nsp2 gene of PRRSV in Ningxia Hui Autonomous Region of China
title_full Genetic variation analyses of nsp2 gene of PRRSV in Ningxia Hui Autonomous Region of China
title_fullStr Genetic variation analyses of nsp2 gene of PRRSV in Ningxia Hui Autonomous Region of China
title_full_unstemmed Genetic variation analyses of nsp2 gene of PRRSV in Ningxia Hui Autonomous Region of China
title_short Genetic variation analyses of nsp2 gene of PRRSV in Ningxia Hui Autonomous Region of China
title_sort genetic variation analyses of nsp2 gene of prrsv in ningxia hui autonomous region of china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091468/
http://dx.doi.org/10.1007/s12250-009-3017-4
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