Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs

The aggregation of the protein α-synuclein (α-Syn) leads to different synucleinopathies. We recently showed that structurally distinct fibrillar α-Syn polymorphs trigger either Parkinson’s disease or multiple system atrophy hallmarks in vivo. Here, we establish a structural-molecular basis for these...

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Detalles Bibliográficos
Autores principales: Shrivastava, Amulya Nidhi, Bousset, Luc, Renner, Marianne, Redeker, Virginie, Savistchenko, Jimmy, Triller, Antoine, Melki, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091477/
https://www.ncbi.nlm.nih.gov/pubmed/32059758
http://dx.doi.org/10.1016/j.bpj.2020.01.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091477/
https://www.ncbi.nlm.nih.gov/pubmed/32059758
http://dx.doi.org/10.1016/j.bpj.2020.01.022

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