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Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs
The aggregation of the protein α-synuclein (α-Syn) leads to different synucleinopathies. We recently showed that structurally distinct fibrillar α-Syn polymorphs trigger either Parkinson’s disease or multiple system atrophy hallmarks in vivo. Here, we establish a structural-molecular basis for these...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Biophysical Society
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091477/ https://www.ncbi.nlm.nih.gov/pubmed/32059758 http://dx.doi.org/10.1016/j.bpj.2020.01.022 |