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Peripheral Determinants of Oxygen Utilization in Heart Failure With Preserved Ejection Fraction: Central Role of Adiposity
The aim of this study was to determine the arteriovenous oxygen content difference (ΔAVo(2)) in adult subjects with and without heart failure with preserved ejection fraction (HFpEF) during systemic and forearm exercise. Subjects with HFpEF had reduced ΔAVo(2). Forearm diffusional conductance for ox...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091498/ https://www.ncbi.nlm.nih.gov/pubmed/32215346 http://dx.doi.org/10.1016/j.jacbts.2020.01.003 |
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author | Zamani, Payman Proto, Elizabeth A. Mazurek, Jeremy A. Prenner, Stuart B. Margulies, Kenneth B. Townsend, Raymond R. Kelly, Daniel P. Arany, Zoltan Poole, David C. Wagner, Peter D. Chirinos, Julio A. |
author_facet | Zamani, Payman Proto, Elizabeth A. Mazurek, Jeremy A. Prenner, Stuart B. Margulies, Kenneth B. Townsend, Raymond R. Kelly, Daniel P. Arany, Zoltan Poole, David C. Wagner, Peter D. Chirinos, Julio A. |
author_sort | Zamani, Payman |
collection | PubMed |
description | The aim of this study was to determine the arteriovenous oxygen content difference (ΔAVo(2)) in adult subjects with and without heart failure with preserved ejection fraction (HFpEF) during systemic and forearm exercise. Subjects with HFpEF had reduced ΔAVo(2). Forearm diffusional conductance for oxygen, a lumped conductance parameter that incorporates all impediments to the movement of oxygen from red blood cells in skeletal muscle capillaries into the mitochondria within myocytes, was estimated. Forearm diffusional conductance for oxygen was not different among adults with HFpEF, those with hypertension, and healthy control subjects; therefore, diffusional conductance cannot explain the reduced forearm ΔAVo(2). Instead, adiposity was strongly associated with ΔAVo(2), suggesting an active role for adipose tissue in reducing exercise capacity in patients with HFpEF. |
format | Online Article Text |
id | pubmed-7091498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-70914982020-03-25 Peripheral Determinants of Oxygen Utilization in Heart Failure With Preserved Ejection Fraction: Central Role of Adiposity Zamani, Payman Proto, Elizabeth A. Mazurek, Jeremy A. Prenner, Stuart B. Margulies, Kenneth B. Townsend, Raymond R. Kelly, Daniel P. Arany, Zoltan Poole, David C. Wagner, Peter D. Chirinos, Julio A. JACC Basic Transl Sci CLINICAL RESEARCH The aim of this study was to determine the arteriovenous oxygen content difference (ΔAVo(2)) in adult subjects with and without heart failure with preserved ejection fraction (HFpEF) during systemic and forearm exercise. Subjects with HFpEF had reduced ΔAVo(2). Forearm diffusional conductance for oxygen, a lumped conductance parameter that incorporates all impediments to the movement of oxygen from red blood cells in skeletal muscle capillaries into the mitochondria within myocytes, was estimated. Forearm diffusional conductance for oxygen was not different among adults with HFpEF, those with hypertension, and healthy control subjects; therefore, diffusional conductance cannot explain the reduced forearm ΔAVo(2). Instead, adiposity was strongly associated with ΔAVo(2), suggesting an active role for adipose tissue in reducing exercise capacity in patients with HFpEF. Elsevier 2020-03-23 /pmc/articles/PMC7091498/ /pubmed/32215346 http://dx.doi.org/10.1016/j.jacbts.2020.01.003 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | CLINICAL RESEARCH Zamani, Payman Proto, Elizabeth A. Mazurek, Jeremy A. Prenner, Stuart B. Margulies, Kenneth B. Townsend, Raymond R. Kelly, Daniel P. Arany, Zoltan Poole, David C. Wagner, Peter D. Chirinos, Julio A. Peripheral Determinants of Oxygen Utilization in Heart Failure With Preserved Ejection Fraction: Central Role of Adiposity |
title | Peripheral Determinants of Oxygen Utilization in Heart Failure With Preserved Ejection Fraction: Central Role of Adiposity |
title_full | Peripheral Determinants of Oxygen Utilization in Heart Failure With Preserved Ejection Fraction: Central Role of Adiposity |
title_fullStr | Peripheral Determinants of Oxygen Utilization in Heart Failure With Preserved Ejection Fraction: Central Role of Adiposity |
title_full_unstemmed | Peripheral Determinants of Oxygen Utilization in Heart Failure With Preserved Ejection Fraction: Central Role of Adiposity |
title_short | Peripheral Determinants of Oxygen Utilization in Heart Failure With Preserved Ejection Fraction: Central Role of Adiposity |
title_sort | peripheral determinants of oxygen utilization in heart failure with preserved ejection fraction: central role of adiposity |
topic | CLINICAL RESEARCH |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091498/ https://www.ncbi.nlm.nih.gov/pubmed/32215346 http://dx.doi.org/10.1016/j.jacbts.2020.01.003 |
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