Cargando…

Estrogen Receptor-α Non-Nuclear Signaling Confers Cardioprotection and Is Essential to cGMP-PDE5 Inhibition Efficacy

Using genetically engineered mice lacking estrogen receptor-α non-nuclear signaling, this study demonstrated that estrogen receptor−α non-nuclear signaling activated myocardial cyclic guanosine monophosphate-dependent protein kinase G and conferred protection against cardiac remodeling induced by pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fukuma, Nobuaki, Takimoto, Eiki, Ueda, Kazutaka, Liu, Pangyen, Tajima, Miyu, Otsu, Yu, Kariya, Taro, Harada, Mutsuo, Toko, Haruhiro, Koga, Kaori, Blanton, Robert M., Karas, Richard H., Komuro, Issei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	PRECLINICAL RESEARCH
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091505/ https://www.ncbi.nlm.nih.gov/pubmed/32215350 http://dx.doi.org/10.1016/j.jacbts.2019.12.009

Ejemplares similares

Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury
por: Liu, Pang-Yen, et al.
Publicado: (2022)

PDE5 says NO to cGMP
por: LeBrasseur, Nicole
Publicado: (2003)

The role of cGMP and PKG in cardioprotection
por: Downey, James M, et al.
Publicado: (2009)

Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury
por: Hara, Hironori, et al.
Publicado: (2018)

Regulatory Actions of Estrogen Receptor Signaling in the Cardiovascular System
por: Ueda, Kazutaka, et al.
Publicado: (2020)

Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling
por: Mullershausen, Florian, et al.
Publicado: (2003)

Membrane-Initiated Estrogen Receptor Signaling Mediates Metabolic Homeostasis via Central Activation of Protein Phosphatase 2A
por: Ueda, Kazutaka, et al.
Publicado: (2018)

PDE3 is the major cGMP-PDE in adult mouse ventricular cardiomyocytes
por: Götz, Konrad R, et al.
Publicado: (2013)

cGMP kinase I, cardiac hypertrophy and PDE inhibition
por: Patrucco, Enrico, et al.
Publicado: (2011)

PDE2, a component of the NO/cGMP signalling in the hippocampus
por: Schönle, Isabel, et al.
Publicado: (2011)

cGMP-PKG upregulates PGC1α and improves cardiac function in advanced cardiac hypertrophy independently of RGS2
por: Takimoto, Eiki
Publicado: (2011)

Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes
por: Pavlaki, Nikoleta, et al.
Publicado: (2018)

Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP efflux
por: Subbotina, Anna, et al.
Publicado: (2017)

cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway
por: Park, Min, et al.
Publicado: (2018)

Role of Ser102 and Ser104 as Regulators of cGMP Hydrolysis by PDE5A
por: Carøe Nordgaard, Julie, et al.
Publicado: (2014)

Asymmetric properties of rod cGMP Phosphodiesterase 6 (PDE6): structural and functional analysis
por: Qureshi, Bilal M, et al.
Publicado: (2015)

Therapeutic Implications for PDE2 and cGMP/cAMP Mediated Crosstalk in Cardiovascular Diseases
por: Sadek, Mirna S., et al.
Publicado: (2020)

β(3)-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes
por: Schobesberger, Sophie, et al.
Publicado: (2020)

The NO/cGMP/PKG pathway in platelets: The therapeutic potential of PDE5 inhibitors in platelet disorders
por: Degjoni, Anisa, et al.
Publicado: (2022)

Rise of cGMP by partial phosphodiesterase-3A degradation enhances cardioprotection during hypoxia
por: Bork, Nadja I., et al.
Publicado: (2021)

The NO/cGMP pathway inhibits transient cAMP signals through the activation of PDE2 in striatal neurons
por: Polito, Marina, et al.
Publicado: (2013)

cGMP-Prkg1 signaling PDE5 inhibition shelter cochlear hair cells and hearing function
por: Knipper, Marlies, et al.
Publicado: (2013)

Modulation of cGMP/cAMP crosstalk on the level of PDE3 in animals lacking NO-sensitive guanylyl cyclase
por: Friebe, Andreas, et al.
Publicado: (2015)

Assessment of the Role of NO-cGMP Pathway in Orthodontic Tooth Movement Using PDE5 Inhibitors: An Animal Study
por: Mirhashemi, Amir Hossein, et al.
Publicado: (2016)

Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection
por: Foulke-Abel, Jennifer, et al.
Publicado: (2020)

Burn-Induced Cardiac Mitochondrial Dysfunction via Interruption of the PDE5A-cGMP-PKG Pathway
por: Wen, Jake J., et al.
Publicado: (2020)

Stimulation of Erythrocyte Soluble Guanylyl Cyclase Induces cGMP Export and Cardioprotection in Type 2 Diabetes
por: Jiao, Tong, et al.
Publicado: (2023)

NO/cGMP signalling in platelets
por: Schinner, Elisabeth, et al.
Publicado: (2009)

cGMP and cardiac hypertrophy
por: Perera, Ruwan K, et al.
Publicado: (2015)

Protein Kinase G Iα Inhibits Pressure Overload–Induced Cardiac Remodeling and Is Required for the Cardioprotective Effect of Sildenafil In Vivo
por: Blanton, Robert M., et al.
Publicado: (2012)

Analysis of cGMP signalling with transgenic mice expressing FRET-based cGMP sensors
por: Wen, Lai, et al.
Publicado: (2013)

Cardioprotection Achieved Through Overexpression of Relaxin Receptors
por: Du, Xiao-Jun
Publicado: (2022)

Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis
por: Egbert, Jeremy R., et al.
Publicado: (2016)

Targeting the SARS-CoV-2 3CL(pro) and NO/cGMP/PDE5 pathway in COVID-19: a commentary on PDE5 inhibitors
por: Shirvaliloo, Milad
Publicado: (2021)

Inhibition of transforming growth factor-β signaling in myeloid cells ameliorates aortic aneurysmal formation in Marfan syndrome
por: Hara, Hironori, et al.
Publicado: (2020)

The Delta Subunit of Rod-Specific Photoreceptor cGMP Phosphodiesterase (PDE6D) Contributes to Hepatocellular Carcinoma Progression
por: Dietrich, Peter, et al.
Publicado: (2019)

Treatment of Cardiovascular Dysfunction With PDE5-Inhibitors – Temperature Dependent Effects on Transport and Metabolism of cAMP and cGMP
por: Selli, Anders L., et al.
Publicado: (2021)

Comparison of critical biomarkers in 2 erectile dysfunction models based on GEO and NOS-cGMP-PDE5 pathway
por: Wang, Guangying, et al.
Publicado: (2021)

Cyclic GMP and PKG Signaling in Heart Failure
por: Numata, Genri, et al.
Publicado: (2022)

Transient kinetics of a cGMP-dependent cGMP-specific phosphodiesterase from Dictyostelium discoideum
Publicado: (1984)

Cannot write session to /tmp/vufind_sessions/sess_t9u7ju5i9f036mqb4uabkrsphe