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Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast
The induction of the beneficial and detrimental effects by reactive carbonyl species in yeast has been investigated. In this study, we have presented evidence that glyoxal and methylglyoxal at low concentrations were able to induce a hormetic adaptive response in glucose-grown but not fructose-grown...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091552/ https://www.ncbi.nlm.nih.gov/pubmed/32231465 http://dx.doi.org/10.1155/2020/4275194 |
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author | Semchyshyn, Halyna |
author_facet | Semchyshyn, Halyna |
author_sort | Semchyshyn, Halyna |
collection | PubMed |
description | The induction of the beneficial and detrimental effects by reactive carbonyl species in yeast has been investigated. In this study, we have presented evidence that glyoxal and methylglyoxal at low concentrations were able to induce a hormetic adaptive response in glucose-grown but not fructose-grown yeast. The hormetic effect was also TOR-dependent. The mutation in genes encoding either TOR1 or TOR2 protein makes yeast highly sensitive to both α-dicarbonyls studied. Simultaneous disruption of TOR1 and TOR2 resulted in higher yeast sensitivity to the α-dicarbonyls as compared to parental cells, but double mutant survived better under carbonyl stress than its single mutant counterparts. The data obtained are consistent with the previous works which reported high toxicity of the α-dicarbonyls and extend them with the report on the beneficial TOR-dependent hormetic effect of glyoxal and methylglyoxal. |
format | Online Article Text |
id | pubmed-7091552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-70915522020-03-30 Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast Semchyshyn, Halyna ScientificWorldJournal Research Article The induction of the beneficial and detrimental effects by reactive carbonyl species in yeast has been investigated. In this study, we have presented evidence that glyoxal and methylglyoxal at low concentrations were able to induce a hormetic adaptive response in glucose-grown but not fructose-grown yeast. The hormetic effect was also TOR-dependent. The mutation in genes encoding either TOR1 or TOR2 protein makes yeast highly sensitive to both α-dicarbonyls studied. Simultaneous disruption of TOR1 and TOR2 resulted in higher yeast sensitivity to the α-dicarbonyls as compared to parental cells, but double mutant survived better under carbonyl stress than its single mutant counterparts. The data obtained are consistent with the previous works which reported high toxicity of the α-dicarbonyls and extend them with the report on the beneficial TOR-dependent hormetic effect of glyoxal and methylglyoxal. Hindawi 2020-03-12 /pmc/articles/PMC7091552/ /pubmed/32231465 http://dx.doi.org/10.1155/2020/4275194 Text en Copyright © 2020 Halyna Semchyshyn. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Semchyshyn, Halyna Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast |
title | Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast |
title_full | Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast |
title_fullStr | Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast |
title_full_unstemmed | Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast |
title_short | Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast |
title_sort | reactive carbonyls induce tor- and carbohydrate-dependent hormetic response in yeast |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091552/ https://www.ncbi.nlm.nih.gov/pubmed/32231465 http://dx.doi.org/10.1155/2020/4275194 |
work_keys_str_mv | AT semchyshynhalyna reactivecarbonylsinducetorandcarbohydratedependenthormeticresponseinyeast |