Cargando…

Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast

The induction of the beneficial and detrimental effects by reactive carbonyl species in yeast has been investigated. In this study, we have presented evidence that glyoxal and methylglyoxal at low concentrations were able to induce a hormetic adaptive response in glucose-grown but not fructose-grown...

Descripción completa

Detalles Bibliográficos
Autor principal: Semchyshyn, Halyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091552/
https://www.ncbi.nlm.nih.gov/pubmed/32231465
http://dx.doi.org/10.1155/2020/4275194
_version_ 1783510030528544768
author Semchyshyn, Halyna
author_facet Semchyshyn, Halyna
author_sort Semchyshyn, Halyna
collection PubMed
description The induction of the beneficial and detrimental effects by reactive carbonyl species in yeast has been investigated. In this study, we have presented evidence that glyoxal and methylglyoxal at low concentrations were able to induce a hormetic adaptive response in glucose-grown but not fructose-grown yeast. The hormetic effect was also TOR-dependent. The mutation in genes encoding either TOR1 or TOR2 protein makes yeast highly sensitive to both α-dicarbonyls studied. Simultaneous disruption of TOR1 and TOR2 resulted in higher yeast sensitivity to the α-dicarbonyls as compared to parental cells, but double mutant survived better under carbonyl stress than its single mutant counterparts. The data obtained are consistent with the previous works which reported high toxicity of the α-dicarbonyls and extend them with the report on the beneficial TOR-dependent hormetic effect of glyoxal and methylglyoxal.
format Online
Article
Text
id pubmed-7091552
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-70915522020-03-30 Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast Semchyshyn, Halyna ScientificWorldJournal Research Article The induction of the beneficial and detrimental effects by reactive carbonyl species in yeast has been investigated. In this study, we have presented evidence that glyoxal and methylglyoxal at low concentrations were able to induce a hormetic adaptive response in glucose-grown but not fructose-grown yeast. The hormetic effect was also TOR-dependent. The mutation in genes encoding either TOR1 or TOR2 protein makes yeast highly sensitive to both α-dicarbonyls studied. Simultaneous disruption of TOR1 and TOR2 resulted in higher yeast sensitivity to the α-dicarbonyls as compared to parental cells, but double mutant survived better under carbonyl stress than its single mutant counterparts. The data obtained are consistent with the previous works which reported high toxicity of the α-dicarbonyls and extend them with the report on the beneficial TOR-dependent hormetic effect of glyoxal and methylglyoxal. Hindawi 2020-03-12 /pmc/articles/PMC7091552/ /pubmed/32231465 http://dx.doi.org/10.1155/2020/4275194 Text en Copyright © 2020 Halyna Semchyshyn. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Semchyshyn, Halyna
Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast
title Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast
title_full Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast
title_fullStr Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast
title_full_unstemmed Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast
title_short Reactive Carbonyls Induce TOR- and Carbohydrate-Dependent Hormetic Response in Yeast
title_sort reactive carbonyls induce tor- and carbohydrate-dependent hormetic response in yeast
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091552/
https://www.ncbi.nlm.nih.gov/pubmed/32231465
http://dx.doi.org/10.1155/2020/4275194
work_keys_str_mv AT semchyshynhalyna reactivecarbonylsinducetorandcarbohydratedependenthormeticresponseinyeast