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Evolutionary implications of Avian Infectious Bronchitis Virus (AIBV) analysis
For developing efficient vaccines, it is essential to identify which amino acid changes are most important to the survival of the virus. We investigate the amino acid substitution features in the Avian Infectious Bronchitis Virus (AIBV) antigenic domain of a vaccine serotype (DE072) and a virulent v...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091586/ https://www.ncbi.nlm.nih.gov/pubmed/16541132 http://dx.doi.org/10.1038/sj.cr.7310041 |
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author | Shi, Peng Yu, Li Fu, Yun-xin Huang, Jing-Fei Zhang, Ke-Qin Zhang, Ya-ping |
author_facet | Shi, Peng Yu, Li Fu, Yun-xin Huang, Jing-Fei Zhang, Ke-Qin Zhang, Ya-ping |
author_sort | Shi, Peng |
collection | PubMed |
description | For developing efficient vaccines, it is essential to identify which amino acid changes are most important to the survival of the virus. We investigate the amino acid substitution features in the Avian Infectious Bronchitis Virus (AIBV) antigenic domain of a vaccine serotype (DE072) and a virulent viral strain (GA98) to better understand adaptive evolution of AIBV. In addition, the SARS Coronavirus (SARS-CoV) was also analyzed in the same way. It is interesting to find that extreme comparability exists between AIBV and SARS in amino acid substitution pattern. It suggests that amino acid changes that result in overall shift of residue charge and polarity should be paid special attention to during the development of vaccines. |
format | Online Article Text |
id | pubmed-7091586 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70915862020-03-24 Evolutionary implications of Avian Infectious Bronchitis Virus (AIBV) analysis Shi, Peng Yu, Li Fu, Yun-xin Huang, Jing-Fei Zhang, Ke-Qin Zhang, Ya-ping Cell Res Article For developing efficient vaccines, it is essential to identify which amino acid changes are most important to the survival of the virus. We investigate the amino acid substitution features in the Avian Infectious Bronchitis Virus (AIBV) antigenic domain of a vaccine serotype (DE072) and a virulent viral strain (GA98) to better understand adaptive evolution of AIBV. In addition, the SARS Coronavirus (SARS-CoV) was also analyzed in the same way. It is interesting to find that extreme comparability exists between AIBV and SARS in amino acid substitution pattern. It suggests that amino acid changes that result in overall shift of residue charge and polarity should be paid special attention to during the development of vaccines. Nature Publishing Group UK 2006-03-16 2006-03 /pmc/articles/PMC7091586/ /pubmed/16541132 http://dx.doi.org/10.1038/sj.cr.7310041 Text en © Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2006 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Shi, Peng Yu, Li Fu, Yun-xin Huang, Jing-Fei Zhang, Ke-Qin Zhang, Ya-ping Evolutionary implications of Avian Infectious Bronchitis Virus (AIBV) analysis |
title | Evolutionary implications of Avian Infectious Bronchitis Virus (AIBV) analysis |
title_full | Evolutionary implications of Avian Infectious Bronchitis Virus (AIBV) analysis |
title_fullStr | Evolutionary implications of Avian Infectious Bronchitis Virus (AIBV) analysis |
title_full_unstemmed | Evolutionary implications of Avian Infectious Bronchitis Virus (AIBV) analysis |
title_short | Evolutionary implications of Avian Infectious Bronchitis Virus (AIBV) analysis |
title_sort | evolutionary implications of avian infectious bronchitis virus (aibv) analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091586/ https://www.ncbi.nlm.nih.gov/pubmed/16541132 http://dx.doi.org/10.1038/sj.cr.7310041 |
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