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Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients
Hematopoietic stem cell transplant (HSCT) recipients are at increased risk of respiratory viral infections and their associated complications. Unlike other respiratory viruses, little is known about the clinical significance of human coronavirus infection (HCoV) in this population. We retrospectivel...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091595/ https://www.ncbi.nlm.nih.gov/pubmed/30385869 http://dx.doi.org/10.1038/s41409-018-0386-z |
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author | Eichenberger, Emily M. Soave, Rosemary Zappetti, Dana Small, Catherine B. Shore, Tsiporah van Besien, Koen Douglass, Claire Westblade, Lars F. Satlin, Michael J. |
author_facet | Eichenberger, Emily M. Soave, Rosemary Zappetti, Dana Small, Catherine B. Shore, Tsiporah van Besien, Koen Douglass, Claire Westblade, Lars F. Satlin, Michael J. |
author_sort | Eichenberger, Emily M. |
collection | PubMed |
description | Hematopoietic stem cell transplant (HSCT) recipients are at increased risk of respiratory viral infections and their associated complications. Unlike other respiratory viruses, little is known about the clinical significance of human coronavirus infection (HCoV) in this population. We retrospectively identified all HSCT recipients who were transplanted between May 2013 and June 2017 at our institution and characterized the cumulative incidence of post-transplant HCoV infection. Of 678 patients who underwent HSCT during the study period, 112 (17%) developed HCoV infection, making HCoV the fourth most common respiratory viral infection. Thirty-four (30%) HCoV-infected patients progressed to proven or probable lower respiratory tract infection (LRTI). Age ≥50, graft-versus-host disease, corticosteroids, hypoalbuminemia, and inpatient status at the time of infection were independently associated with progression to LRTI. Twenty-seven (59%) patients who underwent repeat NP swab had persistent viral shedding for ≥21 days, with a median duration of 4 weeks of viral shedding. We conclude that HCoV is common and clinically significant in HSCT recipients, with nearly one-third of patients progressing to proven or probable LRTI. Evaluating for LRTI risk factors found in this study may identify patients who require closer surveillance and aggressive supportive care when infected with HCoV. |
format | Online Article Text |
id | pubmed-7091595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70915952020-03-24 Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients Eichenberger, Emily M. Soave, Rosemary Zappetti, Dana Small, Catherine B. Shore, Tsiporah van Besien, Koen Douglass, Claire Westblade, Lars F. Satlin, Michael J. Bone Marrow Transplant Article Hematopoietic stem cell transplant (HSCT) recipients are at increased risk of respiratory viral infections and their associated complications. Unlike other respiratory viruses, little is known about the clinical significance of human coronavirus infection (HCoV) in this population. We retrospectively identified all HSCT recipients who were transplanted between May 2013 and June 2017 at our institution and characterized the cumulative incidence of post-transplant HCoV infection. Of 678 patients who underwent HSCT during the study period, 112 (17%) developed HCoV infection, making HCoV the fourth most common respiratory viral infection. Thirty-four (30%) HCoV-infected patients progressed to proven or probable lower respiratory tract infection (LRTI). Age ≥50, graft-versus-host disease, corticosteroids, hypoalbuminemia, and inpatient status at the time of infection were independently associated with progression to LRTI. Twenty-seven (59%) patients who underwent repeat NP swab had persistent viral shedding for ≥21 days, with a median duration of 4 weeks of viral shedding. We conclude that HCoV is common and clinically significant in HSCT recipients, with nearly one-third of patients progressing to proven or probable LRTI. Evaluating for LRTI risk factors found in this study may identify patients who require closer surveillance and aggressive supportive care when infected with HCoV. Nature Publishing Group UK 2018-11-01 2019 /pmc/articles/PMC7091595/ /pubmed/30385869 http://dx.doi.org/10.1038/s41409-018-0386-z Text en © Springer Nature Limited 2018 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Eichenberger, Emily M. Soave, Rosemary Zappetti, Dana Small, Catherine B. Shore, Tsiporah van Besien, Koen Douglass, Claire Westblade, Lars F. Satlin, Michael J. Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients |
title | Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients |
title_full | Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients |
title_fullStr | Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients |
title_full_unstemmed | Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients |
title_short | Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients |
title_sort | incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091595/ https://www.ncbi.nlm.nih.gov/pubmed/30385869 http://dx.doi.org/10.1038/s41409-018-0386-z |
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