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Engineering protein nanocages as carriers for biomedical applications

Protein nanocages have been explored as potential carriers in biomedicine. Formed by the self-assembly of protein subunits, the caged structure has three surfaces that can be engineered: the interior, the exterior and the intersubunit. Therapeutic and diagnostic molecules have been loaded in the int...

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Detalles Bibliográficos
Autores principales: Bhaskar, Sathyamoorthy, Lim, Sierin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091667/
https://www.ncbi.nlm.nih.gov/pubmed/32218880
http://dx.doi.org/10.1038/am.2016.128
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author Bhaskar, Sathyamoorthy
Lim, Sierin
author_facet Bhaskar, Sathyamoorthy
Lim, Sierin
author_sort Bhaskar, Sathyamoorthy
collection PubMed
description Protein nanocages have been explored as potential carriers in biomedicine. Formed by the self-assembly of protein subunits, the caged structure has three surfaces that can be engineered: the interior, the exterior and the intersubunit. Therapeutic and diagnostic molecules have been loaded in the interior of nanocages, while their external surfaces have been engineered to enhance their biocompatibility and targeting abilities. Modifications of the intersubunit interactions have been shown to modulate the self-assembly profile with implications for tuning the molecular release. We review natural and synthetic protein nanocages that have been modified using chemical and genetic engineering techniques to impart non-natural functions that are responsive to the complex cellular microenvironment of malignant cells while delivering molecular cargos with improved efficiencies and minimal toxicity.
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spelling pubmed-70916672020-03-24 Engineering protein nanocages as carriers for biomedical applications Bhaskar, Sathyamoorthy Lim, Sierin NPG Asia Mater Article Protein nanocages have been explored as potential carriers in biomedicine. Formed by the self-assembly of protein subunits, the caged structure has three surfaces that can be engineered: the interior, the exterior and the intersubunit. Therapeutic and diagnostic molecules have been loaded in the interior of nanocages, while their external surfaces have been engineered to enhance their biocompatibility and targeting abilities. Modifications of the intersubunit interactions have been shown to modulate the self-assembly profile with implications for tuning the molecular release. We review natural and synthetic protein nanocages that have been modified using chemical and genetic engineering techniques to impart non-natural functions that are responsive to the complex cellular microenvironment of malignant cells while delivering molecular cargos with improved efficiencies and minimal toxicity. Nature Publishing Group UK 2017-04-07 2017 /pmc/articles/PMC7091667/ /pubmed/32218880 http://dx.doi.org/10.1038/am.2016.128 Text en © The Author(s) 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Bhaskar, Sathyamoorthy
Lim, Sierin
Engineering protein nanocages as carriers for biomedical applications
title Engineering protein nanocages as carriers for biomedical applications
title_full Engineering protein nanocages as carriers for biomedical applications
title_fullStr Engineering protein nanocages as carriers for biomedical applications
title_full_unstemmed Engineering protein nanocages as carriers for biomedical applications
title_short Engineering protein nanocages as carriers for biomedical applications
title_sort engineering protein nanocages as carriers for biomedical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091667/
https://www.ncbi.nlm.nih.gov/pubmed/32218880
http://dx.doi.org/10.1038/am.2016.128
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