Target selectivity in mRNA silencing

Despite the excitement and promise of RNA interference in treating neurodegenerative disease, disease gene mRNA might resist mRNA silencing. Conventional siRNA design does not uniformly distinguish a mutant from a wild-type allele. CAG expansions in trinucleotide repeat diseases are unselective targ...

Descripción completa

Detalles Bibliográficos
Autor principal: Aronin, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091803/
https://www.ncbi.nlm.nih.gov/pubmed/16520821
http://dx.doi.org/10.1038/sj.gt.3302726
_version_ 1783510063868018688
author Aronin, N
author_facet Aronin, N
author_sort Aronin, N
collection PubMed
description Despite the excitement and promise of RNA interference in treating neurodegenerative disease, disease gene mRNA might resist mRNA silencing. Conventional siRNA design does not uniformly distinguish a mutant from a wild-type allele. CAG expansions in trinucleotide repeat diseases are unselective targets for small siRNAs. This review will consider recent discoveries in mechanisms of RNA interference and siRNA modifications that improve siRNA selectivity, delivery and performance.
format Online
Article
Text
id pubmed-7091803
institution National Center for Biotechnology Information
language English
publishDate 2006
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-70918032020-03-24 Target selectivity in mRNA silencing Aronin, N Gene Ther Article Despite the excitement and promise of RNA interference in treating neurodegenerative disease, disease gene mRNA might resist mRNA silencing. Conventional siRNA design does not uniformly distinguish a mutant from a wild-type allele. CAG expansions in trinucleotide repeat diseases are unselective targets for small siRNAs. This review will consider recent discoveries in mechanisms of RNA interference and siRNA modifications that improve siRNA selectivity, delivery and performance. Nature Publishing Group UK 2006-02-16 2006 /pmc/articles/PMC7091803/ /pubmed/16520821 http://dx.doi.org/10.1038/sj.gt.3302726 Text en © Nature Publishing Group 2006 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Aronin, N
Target selectivity in mRNA silencing
title Target selectivity in mRNA silencing
title_full Target selectivity in mRNA silencing
title_fullStr Target selectivity in mRNA silencing
title_full_unstemmed Target selectivity in mRNA silencing
title_short Target selectivity in mRNA silencing
title_sort target selectivity in mrna silencing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091803/
https://www.ncbi.nlm.nih.gov/pubmed/16520821
http://dx.doi.org/10.1038/sj.gt.3302726
work_keys_str_mv AT aroninn targetselectivityinmrnasilencing

Ejemplares similares