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Target selectivity in mRNA silencing
Despite the excitement and promise of RNA interference in treating neurodegenerative disease, disease gene mRNA might resist mRNA silencing. Conventional siRNA design does not uniformly distinguish a mutant from a wild-type allele. CAG expansions in trinucleotide repeat diseases are unselective targ...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091803/ https://www.ncbi.nlm.nih.gov/pubmed/16520821 http://dx.doi.org/10.1038/sj.gt.3302726 |